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Pharming het aandeel van 2017 deel 2
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JackO1976 schreef op 9 november 2017 10:45 :
Ik heb zo'n voorgevoel dat we vandaag wel eens door de 1,40 richting 1,50 zouden kunnen gaan. Overname geluiden worden sterker in de markt... Dat geeft een nieuwe boost!
waar lees je die overname geluiden?
Persberichtje niet gelezen, vandaag. Als die er al is..
Borbor schreef op 9 november 2017 10:50 :
[...]
waar lees je die overname geluiden?
Dat vraag ik mij ook af, waar...? Donald Duck?
Computers doen hun werk binnen de marge van een halve cent.
Ja lees niks...zie alleen een koers in de min tot nu toe
JackO1976 schreef op 9 november 2017 10:45 :
Ik heb zo'n voorgevoel dat we vandaag wel eens door de 1,40 richting 1,50 zouden kunnen gaan. Overname geluiden worden sterker in de markt... Dat geeft een nieuwe boost!
Ik weet niet op welke markt jij dat dan hoort maar ik kan je wel vertellen dat een overnemende partij doorgaans meer interesse heeft in een bedrijf met aandeelhouders met substantiële belangen. Dat praat een stuk makkelijker dan met een vage massa van 40.000 particulieren.
P-10 Results from an interim analysis of a Ruconest treatment registry in Europe R. Hakl1 , M. Staevska2 , H. Farkas3 , M. Jesenak4 , K. Hrubiskova5 , L. Bellizzi6 , A. Relan6 , M. Cicardi7 1 St. Anne’s University Hospital of Brno, Brno, Czech Republic; 2 University Hospital “Alexandrovska” Medical University of Sofa, Sofa, Bulgaria; 3 Sem- melweis University of Budapest, Budapest, Hungary; 4 University Hospital of Martin, Martin, Slovakia; 5 Bratislava University Hospital, Bratislava, Slovakia; 6 Pharming Technologies BV, Leiden, The Netherlands; 7 Hospital Luigi Sacco University of Milan, Milan, Italy Correspondence: L. Bellizzi (L.bellizzi@pharming.com) Allergy, Asthma & Clinical Immunology 2017, 13(Suppl 2):P-10 Background: Hereditary angioedema (HAE) due to C1 inhibitor defciency (C1-INH-HAE) is characterized by recurrent episodes of disabling and painful swelling. Ruconest is a recombinant human C1 inhibitor that is approved for treatment of HAE attacks. A treatment registry was established in Europe to review the adverse event profle and efcacy of Ruconest following single and repeated treatment with Ruconest. Methods: Patients with C1-INH-HAE were enrolled following a decision to treat with Ruconest and after providing written informed consent. Medical history and baseline HAE information was collected at a screening visit. Treatment decisions were at the discretion of the health care professionals (HCP) involved in the patients’ care according to their standards for the management of C1-INH-HAE and in line with the approved Ruconest summary of product characteristics. Following treatment with Ruconest, the HCP entered data using a web-based questionnaire about the attack, response to therapy, and any adverse events. Results: As of 28 February 2017, 45 C1-INH-HAE patients (18 male/27 female, ages 22–76 years) were treated with Ruconest in the registry for 1351 attacks in 7 European countries. The average age at diagnosis for these patients was 24 years (range 4–68). Prior to entry in the registry, these patients experienced an average of 30 HAE attacks in the preceding year. Of the treated patients, 28.8% were on maintenance therapy/prophylaxis at enrollment. There were 653 (48.3%) abdominal, 528 (39%) peripheral, 203 (15%)facial, 21 (1.6%) laryngeal, and 24 (1.8%) urogenital attacks, including 76 attacks that involved two and one attack that involved three locations. The mean Ruconest dose provided was 3268 units 43 U/kg (range 18–67 U/kg), patients reported relief within 4 h in 97.8% (1322/1351) of the attacks. Almost all attacks (1349/1351, 99.8%) were treated with a single dose of Ruconest. Two attacks treated with an initial dose of 2100 U (33 and 28 U/kg) received a second dose of 2100 U. No hypersensitivity or thrombotic/thromboembolic events were reported. No patients had any related serious adverse events. Conclusions: The Ruconest treatment registry provides real-world data on the treatment of 1351 HAE attacks that is consistent with previous reports on the safety and efcacy of Ruconest therapy 1- - 28.8% were on maintenance therapy/prophylaxis at enrollment 2- - patients reported relief within 4 h in 97.8% (1322/1351) of the attacks. Almost all attacks (1349/1351, 99.8%) were treated with a single dose of Ruconest. do we need to say more....Blockbuster !!
Beur schreef op 9 november 2017 10:37 :
[...]De produktie van Cinryze is begin vorige maand al weer hervat.
N weer zuiver????
Ok, dus de koers zou eens gedrukt kunnen worden, morgen. Ik denk dat dit gisteren al is gebezigd. No worries dus.
Eurowin schreef op 9 november 2017 10:51 :
[...]
Dat vraag ik mij ook af, waar...? Donald Duck?
Met een beetje geluk wordt Pharming straks door nieuwe regelgeving beschermd tegen een snelle overname en moet er eerst een jaar "bedenktijd" in acht worden genomen. Tegen die tijd staat het aandeel waarschijnlijk een stuk hoger en wordt de overnameprijs wel erg hoog.
Beur schreef op 9 november 2017 10:37 :
[...]De produktie van Cinryze is begin vorige maand al weer hervat.
De productie mag wellicht hervat zijn. Echter de omzet cijfers van Shire vertellen een groot verlies van de klanten. En de klanten die overgestapt zijn naar Ruconest krijgen ze niet meer terug. Zeker gezien het betere resultaat wat wordt ervaren tov Cinryze.
Beur schreef op 9 november 2017 10:37 :
[...]De produktie van Cinryze is begin vorige maand al weer hervat.
C1-Esterase Inhibitor (Human) Cinryze® NDC Number: 42227-081-05 1 Vial, Single-use in 1 Carton NDC Number: 42227-081-01 5 mL in 1 Vial, Single-use ViroPharma Biologics, Inc., a subsidiary of Shire Pharmaceuticals. For questions, please call Shire customer service at: 1-866-888-0660 Cinryze® C1-Esterase Inhibitor (Human) is currently unavailable. Other Questions, please call Shire Pharmaceuticals directly at 1-866-888-0660. Additional information may be found here:www.fda.gov/ BiologicsBloodVaccines /SafetyAvailability/ ucm576349.htm Onset: April 2017 Updated: September 2017 Ongoing dan mag jij me dat eens zwart op wit laten zien..ps en niet de uitspraak vd ceo daar veeg ik me .......
P1_2015 schreef op 9 november 2017 10:56 :
[...]
De productie mag wellicht hervat zijn.
Echter de omzet cijfers van Shire vertellen een groot verlies van de klanten.
En de klanten die overgestapt zijn naar Ruconest krijgen ze niet meer terug. Zeker gezien het betere resultaat wat wordt ervaren tov Cinryze.
Ja maar dat mag je van onze ouwe beur niet zeggen.Die heb liever dat niet iedereen weet dat het Super met het medicijn gaat,gelukkig voor de Patiënten!!!
Vergelijkbaar patroon met gisteren. Straks weer omhoog.
Begrijp ik het goed dat de shares increase vanwege de Warrants een positief effect hebben op de netto jaarresultaten?
Home treatment with conestat alfa in attacks of hereditary angioedema due to C1-inhibitor defciency Background: Conestat alfa, a recombinant C1-inhibitor (rhC1-INH) is a novel therapeutic option for the acute treatment of hereditary angioedema due to C1-INH defciency (HAE-C1-INH). Our aim was to continue to investigate the efcacy and safety of conestat alfa administered as acute treatment under real-life conditions to relieve angioedema attacks in patients with C1-INH-HAE. Materials and methods: We analyzed 376 edematous episodes requiring acute treatment and occurring in 7 C1-INH-HAE patients. The patients were treated at home with a dose 2100 U rhC1-INH per occasion. The patients recorded the time of rhC1-INH administration; the time to the onset of improvement and to the complete resolution of symptoms; and noted any side efects. Symptom severity and patient satisfaction were measured with a visual analogue scale (VAS). Results: 165 HAE attacks occurred in abdominal viscera, 9 in the upper airways, 174 in subcutaneous and 62 in multiple locations. RhC1-INH was administered 85.0 (0.0–2910.0) [median (min–max)] minutes after the onset of the attacks with a severity (upon injecting) of 60.0 (10.0–99.0) on a VAS. Clinical symptoms improved within 60.0 (0.0–1320.0) minutes, and the complete resolution of symptoms took 840.0 (60.0–4320.0) minutes. The time between the onset of the attack and the administration of rhC1-INH correlated with the time that symptoms stopped worsening (R = 0.2194, p < 0.0001), with the time that symptoms improve (R = 0.2575 p < 0.0001) and with the time to the complete resolution of symptoms (R = 0.3512, p < 0.0001). Second and third injection of rhC1- INH was administered in 11 and 1 attacks respectively, because symptoms did not improve or resolve completely. In seven cases, rhC1-INH was administered with the aim of prevention before dental procedure. Neither of the cases were followed by edematous attack. None of the patients experienced a recurrence of the attack, or drugrelated systemic adverse events. The mean VAS score of patient satisfaction was 93.1. Conclusions: Home treatment with rhC1-INH was an efective and well-tolerated therapy for all types of HAE attacks. Early treatment of attacks resulted in the better outcomes. 1- - therapy for all types of HAE attacks
Koop nu snel!, straks weer + 8%!
Of-label intramuscular administration of Conestat Alfa (rhC1inh) in HAE patients: a case series Background: Conestat alfa (rhC1inh) is registered for intravenous treatment of hereditary angioedema (HAE) attacks in adult and adolescent patients. Methods: We present a case series of three diferent HAE patients who use of-label intramuscular administration of rhC1inh. Results: Case 1: 32-year old man weighing 60 kg with HAE type I. Intramuscular application of rhC1inh has been practiced since 2015 during peripheral, abdominal and urogenital attacks: when he presumes that an attack is not life-threatening, intramuscular self-administration is preferred. The patient normally injects a 20 ml syringe (3000 U rhC1inh + solvent). Frequent under-dosing is reported (1 vial, 2100 U rhC1inh, reconstituted in 10 ml). The patient self-injects the medication in the middle front third of m. quadriceps femoris. Case 2: A 50 kg, 16-year old girl with HAE type I (daughter of Case 1): during non-severe HAE attacks the father injects 17 ml (2500 U rhC1inh + solvent) in the middle front third of the thigh of his daughter. Again, under-dosing is frequent with good clinical outcome. Case 3: 71-year old HAE type I patient (84 kg) with frequent and severe abdominal attacks (2–3 times per week). The patient sufers compromised veins and difcult peripheral venous access often resulting in treatment impediments. Of-label twice weekly prophylactic intramuscular administration of rhC1inh was initiated after all ethical implications were discussed and this common decision was made. The dose used per application: 4200 U/20 ml (2 vials solved in 10 ml solvent, each) was injected intramuscularly in two diferent sites, either into m. gluteus maximus or m. quadriceps femoris. During the 14-week follow-up no severe breakthrough attacks occurred. The patient reported signifcant improvement in the quality of life and daily activities were restored. No side efects at the application site and from the medication were reported from any of the patients. Conclusions: Intramuscular administration of rhC1inh could be an alternative to the intravenous route of application, especially when intravenous administration is compromised or access to medical care facilities is difficult. Intramuscular application of rhC1inh seems to be safe and effective in the presented cases: as on-demand therapy and in prophylaxis. 2100 U rhC1inh can be successfully solved in 10 ml solvent and the intramuscular application shows no adverse effects. Long-term prophylaxis (LTP) with rhC1inh seems to be safe and effective in subjects with severe HAE. Application of two vials (4200 IU) twice weekly seems to be an effective dose for LTP 1- - safe and effective in the presented cases: as on-demand therapy and in prophylaxis
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