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Aangepaste pipeline Oncoarendioncoarendi.com/en/badania-i-rozwoj-2/ - Galapagos is met een 2nd generation IPF bezig - Oncoarendi optie YKL-40 (Immuno Oncology/IPF) en Nash/CNS bij goede resultaten op termijn aan gaat bieden aan Galapagos Nash, de lever, dat zou volgens mij dan een nieuw onderdeel van Galapagos kunnen gaan worden, (zie onder link search-and-evaluation). (Non-alcoholic steatohepatitis (NASH) is the most severe form of non-alcoholic fatty liver disease)www.cnshealthcare.com/learn-more/diso... Zaak is door te schakelen met IPF en tot een succes te maken, zo kan dit onderdeel opgenomen worden als 2e poot (inkomstenbron) voor Galapagos... ontwikkeld al door extern bedrijf (lees samenwerking/in licentie), kan een hit worden en zal veel meer vertrouwen gaan geven.... is het duur kopen/overnemen van een bedrijf of vergevorderde medicijn dan eigenlijk nog wel nodig? de markt lijkt rekening ermee te houden dat er de komende 3 -> 5 jaar nodig zijn te gaan ontwikkelen ( marktwaarde "koers" nu ca 3 Mrd) oplopende opbrengsten Filgotinib geeft minder Cashburn (onlosmakelijk en altijd met risico's bij bio's). Galapagos zet stevig in op nieuwe ontwikkelingen/samenwerkingen/in-licensingwww.glpg.com/search-and-evaluation OncoArendi kan dan wel eens een fijne partner gaan worden....
Wall Street Trader schreef op 3 september 2021 10:16 :
Drug-drug Interaction and Food-effect Study With GLPG4716 and Midazolam in Healthy Subjects Brief Summary:
The purpose of this study is to determine the effect of the administration of multiple doses of GLPG4716 on the amount of midazolam (MDZ) that gets into the blood when the two drugs are administered together compared to when midazolam is administered alone. Other objectives of this study are to evaluate the safety and tolerability of GLPG4716 when administered with midazolam and assess the amount of GLPG4716 that gets into the blood when administered with midazolam. This study will also assess the effect of food on the amount of GLPG4716 that gets into the blood.
Recruitment Status : Not yet recruiting
First Posted : September 1, 2021
Last Update Posted : September 1, 2021
clinicaltrials.gov/ct2/show/NCT05030857 Ondertussen is deze studie aan het rekruteren
Here is new presentation from Oncoarendi (OAT). Published after latest quarterly financial meeting with investors (4.11.2021) PDF: oncoarendi.com/wp-content/uploads/2021/11/Investor_presentation_20211104_OAT_final.pdf
[quote alias=MrBiggy id=13717024 date=202110021713] Aangepaste pipeline Oncoarendioncoarendi.com/en/badania-i-rozwoj-2/ - Galapagos is met een 2nd generation IPF bezig - Oncoarendi optie YKL-40 (Immuno Oncology/IPF) en Nash/CNS bij goede resultaten op termijn aan gaat bieden aan Galapagos Nash, de lever, dat zou volgens mij dan een nieuw onderdeel van Galapagos kunnen gaan worden, (zie onder link search-and-evaluation). (Non-alcoholic steatohepatitis (NASH) is the most severe form of non-alcoholic fatty liver disease)www.cnshealthcare.com/learn-more/diso... Zaak is door te schakelen met IPF en tot een succes te maken, zo kan dit onderdeel opgenomen worden als 2e poot (inkomstenbron) voor Galapagos... ontwikkeld al door extern bedrijf (lees samenwerking/in licentie), kan een hit worden en zal veel meer vertrouwen gaan geven.... is het duur kopen/overnemen van een bedrijf of vergevorderde medicijn dan eigenlijk nog wel nodig? de markt lijkt rekening ermee te houden dat er de komende 3 -> 5 jaar nodig zijn te gaan ontwikkelen ( marktwaarde "koers" nu ca 3 Mrd) oplopende opbrengsten Filgotinib geeft minder Cashburn (onlosmakelijk en altijd met risico's bij bio's). Galapagos zet stevig in op nieuwe ontwikkelingen/samenwerkingen/in-licensingwww.glpg.com/search-and-evaluation OncoArendi kan dan wel eens een fijne partner Misschien een licentie nemen op Lanifibranor (NASH) van Inventiva .Zeer goede resultaten in fase 2 en is nu in fase 3. Scoorde op alle eindpunten ( steatose, ontsteking , fibrose ) zeer goed .
Looks that GLPG4716 and Midazolam drug-drug interaction study is completed. clinicaltrials.gov/ct2/show/NCT05030857 Step by step we are closer to Phase II...
Onco Arendi is preparing to name change which will much better corresponding to the new strategy. New name will be Molecure S.A. And two new people in supervisory board: Dr Nancy Van Osselaer and Dr Paul Van der Horst. Both previously worked in Galapagos. Source (only in Polish): oncoarendi.com/oncoarendi-therapeutic...
New supervisory board members accepted by shareholders oncoarendi.com/en/oncoarendi-therapeu...
www.ipopemasecurities.pl/media/files/... OncoArendi’s share price has fallen 24% YTD for no apparent reason. We maintain our expectations that the OATD-02 project will enter the clinic next year and a deal could be signed in this project in 2024E. We value the project at PLN 10.7/share. We value the GLPG4716 project at PLN37.9/share and expect a minor milestone from Galapagos in 2022E. We also note the company’s net cash position remained at a high level of PLN101m in 3Q21. We maintain our BUY rating with a fair value of PLN 55/share (unchanged). GLPG4716/OATD-01 (idiopathic pulmonary fibrosis). The company’s most advanced project is GLPG4716 outlicensed to Galapagos, a potential first-in-class chitinase inhibitor which has completed a Phase 1 study in healthy volunteers and is currently being tested in an additional drug-drug interaction study with nintedanib and pirfenidone in healthy subjects. Although the estimated completion date of the interaction study was delayed from October 2021 to June 2022, we continue to assume a 95% probability of its successful completion. In 2022E, we forecast OncoArendi will receive a milestone of EUR 3m from Galapagos. We expect the Phase 2 study in idiopathic pulmonary fibrosis (IPF) to start in 2022E (in line with Galapagos’ plan) and to be completed in 2024E. If the results are positive (probability of success: 39%) we assume OncoArendi will receive a milestone of EUR 12m.
OAT name change is officially done. New WSE ticker name is MOC -> MOLECURE. Fun fact is that in polish MOC is in english POWER :)
Newest investor presentation from Molecure: oncoarendi.com/wp-content/uploads/202...
Drug-drug Interaction GLPG4716 and Nintedanib and Pirfenidone is completed. Now it's Galapagos turn to push it to next phase.clinicaltrials.gov/ct2/show/NCT04971746
Interesting info. New candidate for Molecule supervisory board is working at Gilead Sciences. Source: biznes.pap.pl/espi/pl/reports/view/at... ,20220610_174834_0000511069,20220610 Pawel Trawkowski is a graduate of the Faculty of Marketing and Management at the University of Warsaw with over 20 years of managerial experience and extensive knowledge in the largest, international pharmaceutical companies. For 12 years he has been working at Gilead Sciences where he was various financial positions in Europe and the United States of America ran as well global projects. Currently, he is the Regional Financial Director for the area Europe, Canada and Australia. As part of his duties, he is responsible for all processes in the region, in particular related to planning, analysis and reporting financial services both for the group and local markets. Previously, he worked at Wyeth sp.z o.o. as Finance Director and member of the management board, and then, after the acquisition of Pfizer Polska sp. z o.o.
Very interesting presentation from Molecure: molecure.com/app/uploads/2022/06/mole...
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