Forum: Crucell » Sterke toename vraag "fully liquid"QUINVAXEM » Pagina: 6

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flosz 30 juli 2009 10:48

MeawandMoo1 - 30 jul 09, 07:58

"Post-Eradication IPV Supply Demand - March 2009 DRAFT"

To help frame the economic elements, we can analyze the price of a combination vaccine that would make it economically equivalent to the stand-alone option, referred to as the “breakeven price.” For the purpose of this analysis, we have assumed the combination vaccine would be a hexavalent, which would replace the need for a stand-alone IPV vaccine and current pentavalent. The current average low income, public market price for stand-alone IPV and the non-IPV containing pentavalent combination (fully liquid form) are €2.30 per dose and €2.69 per dose respectively. Programmatically, the use of a hexavalent combination would result in, on average, €0.60 in savings per child vaccinated9. This savings
results from the need to administer less injections, reducing the cost associated with syringes, safety/disposal, cold chain transportation, etc. Combining these inputs with assumptions on wastage and
shipping cost10, a hypothetical hexavalent vaccine would have to be priced at €5.19 per dose to be economically equivalent to the stand-alone option.
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These planned expansions are estimated to increase annual wtIPV capacity by approximately 140 million doses to a total of approximately 260 million doses, most of which would still reside with two suppliers. While capital has already been committed and several of these planned expansions are underway, the wtIPV
manufacturers have indicated that two to three years will be required to ramp-up production to achieve
these levels once they have further clarity around demand. In addition, the manufacturers have voiced
that alternative uses exist for some of this capacity and that they will consider diverting the capacity if
demand does not materialize.
Lastly, some of the existing manufacturers have the potential to expand their capacity even further. For
example, some manufacturers designed their current facilities to accommodate fermenter upgrades and others have discussed constructing new facilities. These potential expansions could further increase capacity by approximately 200 million doses. Such capacity expansion will require new, currently uncommitted capital, and thus is contingent on manufacturers’ expectations of future demand for their products. The wtIPV manufacturers have indicated that a lead-time of three-to-five years will be required to ramp-up production to these levels. All told, with potential expansions, existing wtIPV manufacturers have the flexibility to expand supply to approximately 460 million doses annually (as shown in figure 5), with the majority of capacity residing with a single supplier.

www.who.int/immunization/sage/3_Post-...
www.iex.nl/forum/topic.asp?forum=228&...
www.investorvillage.com/smbd.asp?mb=2...

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Sterke toename vraag "fully liquid"QUINVAXEM

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