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Declan schreef op 2 december 2016 20:55 :
Mooi dat Up moment en gesteund want wat we eerder zagen dat de koers down gezet werd gebeurde dat nu niet.
Wat staat hier nu? Mijn hemel! Tja, up moment, en dan? eerst weer down?, En dan gebeurde dat niet? Wie kan hier aan ontcijferen? Marlanki wellicht, die is schoolmeester. Stel dit weekend positief nieuws dan wordt het een leuke 5 Dec.
Oké, die mogelijkheid bestaat, maar ik denk dat het nieuws van een geslaagde financiering, niet een extra koersboost kan geven. Las ik toch in het frommel stukje van DZR dat Valeant het initiatief nam tot verkoop rechten.
Snap nu wel waarom DZR niet op een gesprekje durfde.
Onzin, de redenen om niet een gesprek met Sijmen aan te gaan zijn hier al eerder duidelijk door hem neer neergezet. Als je zulke onwaarheden om populair te zijn schrijft wat ben je dan aan het doen?
Wat doe jij hier al jaren, en jaren lang op diverse fora? Ze zouden je beter Ruud de Pusher kunnen noemen, i.p.v. ruud declan etc. Jammer want er waren zat redenen te bedenken om te twijfelen, echter nu niet meer.
Hoe kom je hier nu weer op? Weet jij meer dan de rest van de beleggers en investeerders? Dat zou pas een kwalijke zaak zijn, en riekt naar mogelijke voorkennis? (zo als je altijd, z.g. had????) Pharming gaf geen nieuws simpel omdat dat niet kon.
Dit is volkomen correct! Echter het knallen zoals grote Rob meldt komt heel dicht bij.
Grote Rob? Wie bedoel je nu? Wat heeft de z.g. Grote Rob dan gezegd, of wat is zijn record? Houd ook rekening met met een koers IMPLOSIE, als er slecht nieuws komt. Ik hoef jou niets te vertellen daarover. Ruud..
Wat een B.S. zeg! Zie commentaren in BOLD
A Randomized Trial of Subcutaneous C1-INH for HAE Attack Prevention Current options for prophylaxis of acute HAE attacks are very limited. The international, prospective, double-blind, crossover, phase III COMPACT trial evaluated a volume-reduced, subcutaneous C1-inhibitor preparation, CSL830, for the prevention of HAE attacks. After obtaining written consent, patients with type I/II HAE were randomized to one of four treatment sequences, each involving two 16-week treatment periods: 40 IU/kg twice-weekly followed by placebo, or vice versa; or similarly with 60 IU/kg. The primary efficacy endpoint was the time-normalized number of HAE attacks. Secondary efficacy endpoints were the proportion of responders ( at least 50 % reduction in time-normalized number of HAE attacks versus placebo) and time-normalized number of rescue medication uses. Adverse events (AEs) were monitored throughout. Of 90 patients randomized, 79 completed the study. Both doses of CSL830 reduced the time-normalized attack rate versus placebo (both p<0.001); mean difference –2.42 attacks/month (95 % CI: –3.38, –1.46), corresponding to an 89 % median reduction (40 IU/kg), and –3.51 attacks/month (95 % CI: –4.21, –2.81) corresponding to a 95 % median reduction (60 IU/kg). Response rates were 76 % (95 % CI: 62, 87) (40 IU/kg) and 90 % (95 % CI: 77, 96) (60 IU/kg). Need for HAE rescue medication was reduced from 5.55 (placebo) to 1.13 uses/month (40 IU/kg) and from 3.89 (placebo) to 0.32 uses/month (60 IU/kg). AEs were reported in a similar proportion of patients across treatments; most were injection-site reactions, which were generally of mild severity and transient. The self-administered, subcutaneous C1-inhibitor CSL830 was highly efficacious for preventing HAE attacks. (Source: ACAAI oral abstract O002 presented 13 November 2016)
FDA Accepts CSL Behring’s Biologics License Application for First Subcutaneous Prophylactic Therapy to Prevent Hereditary Angioedema Attacks KING OF PRUSSIA, Pa. — 30 August 2016 CSL Behring announced today that the U.S. Food and Drug Administration (FDA) has accepted for review the company’s Biologics License Application (BLA) for its low-volume subcutaneous (SC) C1-Esterase Inhibitor (C1-INH) Human replacement therapy, CSL830, as prophylaxis to prevent Hereditary Angioedema (HAE) attacks. HAE is a rare genetic disorder caused by a deficiency of C1-INH, one of the proteins that work with the body’s immune system to control inflammation. Symptoms of HAE include episodes of swelling in the face, abdomen, larynx and extremities and can be fatal if untreated. “The review of this application is another step towards providing advanced prophylactic treatment options to people living with HAE,” said Dr. Andrew Cuthbertson, Chief Scientific Officer and R&D Director, CSL Limited. “Since CSL Behring first reported the possibility of C1-INH replacement therapy for HAE over 40 years ago, we have remained committed to innovative research and providing advanced treatment options to people living with HAE. Subcutaneous prophylaxis is the next important step in helping HAE patients to prevent HAE attacks.” About Hereditary Angioedema HAE is a rare and potentially life-threatening genetic condition that occurs in about 1 in 10,000 to 1 in 50,000 people. HAE is caused by lack of or malfunctioning C1-INH. As a result, there are inadequate amounts of properly functioning C1-INH, leading fluid to build up in body tissues, causing considerable swelling episodes referred to as angioedema. HAE attacks can affect many parts of the body and can spread to multiple sites, including the face, abdomen, larynx and extremities. Patients who have abdominal attacks of HAE can experience episodes of extreme pain, diarrhea, nausea and vomiting caused by swelling of the intestinal wall. HAE attacks that involve the face or throat can result in airway closure, asphyxiation and, if untreated, death. About Subcutaneous C1 Esterase Inhibitor (C1-INH) C1 Esterase Inhibitor (Human) is an investigational, low-volume, subcutaneous prophylactic therapy. C1-INH replaces the missing or malfunctioning C1-INH protein in patients with a C1-INH deficiency, thereby preventing HAE attacks.
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