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Zei zoeken naar een vaccine

14 Posts
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  1. [verwijderd] 13 april 2020 12:48

    DRAFT landscape of COVID-19 candidate vaccines – 11 April 20203 candidate vaccines in clinical evaluation

    Platform
    Type of candidate vaccine
    Developer
    Coronavirus target
    Current stage of clinical evaluation/regulatory status- Coronavirus candidate
    Same platform for non-Coronavirus candidates
    Non- Replicating Viral Vector

    Adenovirus Type 5 Vector
    CanSino Biological Inc./Beijing Institute of Biotechnology
    COVID-19
    Phase 2
    ChiCTR2000031781
    Phase 1
    ChiCTR2000030906

    Ebola
    DNA
    DNA plasmid vaccine Electroporation device
    Inovio Pharmaceuticals
    COVID-19
    Phase 1
    NCT04336410

    Lassa, Nipah HIV Filovirus HPV
    Cancer indications Zika
    Hepatitis B
    RNA
    LNP- encapsulated mRNA
    Moderna/NIAID
    COVID-19
    Phase 1
    NCT04283461
    multiple candidates
  2. [verwijderd] 13 april 2020 12:50
    Platform
    Type of candidate vaccine
    Developer
    Coronavirus target
    Current stage of clinical evaluation/regulatory status- Coronavirus candidate

    Same platform for non-Coronavirus candidates

    DNA
    DNA with electroporation
    Karolinska Institute / Cobra Biologics (OPENCORONA Project)
    COVID-19
    Pre-Clinical

    DNA
    DNA plasmid vaccine
    Osaka University/ AnGes/ Takara Bio
    COVID-19
    Pre-Clinical
    DNA
    DNA
    Takis/Applied DNA Sciences/Evvivax

    COVID-19

    Pre-Clinical
    DNA
    Plasmid DNA, Needle-Free Delivery
    Immunomic Therapeutics, Inc./EpiVax, Inc./PharmaJet, Inc.
    COVID-19
    Pre-Clinical
    SARS
  3. [verwijderd] 13 april 2020 12:51
    DNA
    DNA plasmid vaccine
    Zydus Cadila
    COVID-19
    Pre-Clinical
    Inactivated

    Inactivated + alum

    Sinovac
    COVID-19

    Pre-Clinical
    SARS
    Inactivated
    Inactivated
    Beijing Institute of Biological Products/Wuhan Institute of Biological Products
    COVID-19
    Pre-Clinical

    Inactivated

    TBD
    Osaka University/ BIKEN/ NIBIOHN

    COVID-19
    Pre-Clinical

    Live Attenuated Virus
    Deoptimized live attenuated vaccines
    Codagenix/Serum Institute of India
    COVID-19
    Pre-Clinical
    HAV, InfA, ZIKV, FMD, SIV, RSV, DENV
    Non- Replicating Viral Vector
    ChAdOx1
    University of Oxford
    COVID-19
    Phase 1/2 (not yet recruiting) NCT04324606


    MERS, influenza, TB, Chikungunya, Zika, MenB, plague

    Non- Replicating Viral Vector
    MVA encoded VLP
    GeoVax/BravoVax
    COVID-19
    Pre-Clinical
    LASV, EBOV, MARV, HIV
    Non- Replicating Viral Vector
    Ad26 (alone or with MVA boost)
    Janssen Pharmaceutical Companies
    COVID-19
    Pre-Clinical

    Ebola, HIV, RSV
    Non- replicating viral vector
    MVA-S encoded
    DZIF – German Center for Infection Research
    COVID-19

    Pre-clinical

    Many
    Non- Replicating Viral Vector
    adenovirus- based NasoVAX expressing SARS2-CoV spike protein
    Altimmune
    COVID-19
    Pre-Clinical
    influenza
    Non- Replicating Viral Vector
    Ad5 S (GREVAXTM platform)
    Greffex
    COVID-19
    Pre-Clinical
    MERS
  4. [verwijderd] 13 april 2020 12:52
    Non- Replicating Viral Vector
    Oral Vaccine platform
    Vaxart
    COVID-19
    Pre-Clinical
    InfA, CHIKV, LASV, NORV; EBOV, RVF, HBV, VEE
    Non- Replicating Viral Vector

    MVA expressing structural proteins

    Centro Nacional Biotecnología (CNB-CSIC), Spain
    COVID-19

    Pre-Clinical
    HIV, HCV, chikungunya, Ebola, zika, malaria, leishmania
    Protein Subunit
    Capsid-like Particle
    AdaptVac (PREVENT-nCoV consortium)
    COVID-19
    Pre-Clinical

    Protein Subunit

    Drosophila S2 insect cell expression system VLPs
    ExpreS2ion

    COVID-19
    Pre-Clinical

    Protein Subunit
    Peptide antigens formulated in lipid nanoparticle formulation
    IMV Inc
    COVID-19
    Pre-Clinical
    Protein Subunit
    S protein
    WRAIR/USAMRIID
    COVID-19
    Pre-Clinical

    Protein Subunit
    S protein +Adjuvant
    National Institute of Infectious Disease, Japan
    COVID-19
    Pre-Clinical

    Influenza

    Protein Subunit
    VLP- recombinant protein + Adjuvant
    Osaka University/ BIKEN/ National Institutes of Biomedical Innovation, Japan
    COVID-19
    Pre-Clinical
    Protein Subunit
    Native like Trimeric subunit Spike Protein vaccine
    Clover Biopharmaceuticals Inc./GSK/Dynavax
    COVID-19
    Pre-Clinical

    HIV, REV Influenza
    Protein Subunit
    microneedle arrays S1 subunit
    Univ. of Pittsburgh
    COVID-19
    Pre-Clinical
    MERS
    Protein Subunit
    Peptide
    Vaxil Bio

    COVID-19

    Pre-Clinical
  5. [verwijderd] 13 april 2020 12:53
    Protein Subunit
    Adjuvanted protein subunit (RBD)
    Biological E Ltd
    COVID-19
    Pre-Clinical
    Protein Subunit

    Peptide

    Flow Pharma Inc
    COVID-19

    Pre-Clinical
    Ebola, Marburg, HIV, Zika, Influenza, HPV therapeutic vaccine, BreastCA vaccine
    Protein Subunit
    S protein
    AJ Vaccines
    COVID-19
    Pre-Clinical

    Protein Subunit

    Ii-Key peptide
    Generex/EpiVax

    COVID-19
    Pre-Clinical
    Influenza, HIV, SARS-CoV

    Protein Subunit
    S protein
    EpiVax/Univ. of Georgia
    COVID-19
    Pre-Clinical
    H7N9
    Protein Subunit
    S protein (baculovirus production)
    Sanofi Pasteur
    COVID-19
    Pre-Clinical

    Influenza, SARS-CoV

    Protein Subunit
    VLP- recombinant protein nanoparticle vaccine + Matrix M
    Novavax
    COVID-19
    Pre-Clinical
    RSV; CCHF, HPV, VZV, EBOV
    Protein Subunit
    gp-96 backbone
    Heat Biologics/Univ. Of Miami
    COVID-19
    Pre-Clinical

    NSCLC, HIV, malaria, Zika
    Protein Subunit
    Molecular clamp stabilized Spike protein
    University of Queensland/GSK/Dynavax
    COVID-19
    Pre-Clinical

    Nipah, influenza, Ebola, Lassa
    Protein Subunit
    S1 or RBD protein
    Baylor College of Medicine
    COVID-19
    Pre-Clinical
    SARS
    Protein Subunit
    Subunit protein, plant produced
    iBio/CC-Pharming

    COVID-19

    Pre-Clinical
  6. [verwijderd] 13 april 2020 12:54
    Protein Subunit
    Recombinant protein, nanoparticles (based on S- protein and other epitopes)
    Saint-Petersburg scientific research institute of vaccines and serums
    COVID-19
    Pre-Clinical
    Protein Subunit
    COVID-19 XWG-03 truncated S (spike) proteins
    Innovax/Xiamen Univ./GSK
    COVID-19
    Pre-Clinical
    HPV
    Protein Subunit
    Adjuvanted microsphere peptide
    VIDO-InterVac, University of Saskatchewan
    COVID-19
    Pre-Clinical
    Protein Subunit

    Synthetic Long Peptide Vaccine candidate for S and M proteins

    OncoGen
    COVID-19

    Pre-Clinical
    Replicating Viral Vector
    Measles Vector
    Zydus Cadila
    COVID-19
    Pre-Clinical

    Replicating Viral Vector
    Measles Vector
    Institute Pasteur/Themis/Univ. of Pittsburg Center for Vaccine Research
    COVID-19
    Pre-Clinical
    West nile, chik, Ebola, Lassa, Zika
    Live attenuated virus
    Measles Virus (S, N targets)
    DZIF – German Center for Infection Research
    COVID-19
    Pre-clinical

    Zika, H7N9, CHIKV

    Replicating Viral Vector
    Horsepox vector expressing S protein
    Tonix Pharma/Southern Research
    COVID-19
    Pre-Clinical
    Smallpox, monkeypox

    Replicating Viral Vector
    Live viral vectored vaccine based on attenuated influenza virus backbone (intranasal)
    BiOCAD and IEM
    COVID-19
    Pre-Clinical
    Replicating Viral Vector
    Influenza vector expressing RBD
    University of Hong Kong

    COVID-19

    Pre-Clinical
    Replicating Viral Vector
    VSV vector expressing S protein
    IAVI/Batavia
    COVID-19
    Pre-Clinical
    Ebola, Marburg, Lassa
  7. [verwijderd] 13 april 2020 12:55
    RNA
    LNP- encapsulated mRNA cocktail encoding VLP
    Fudan University/ Shanghai JiaoTong University/RNACure Biopharma
    COVID-19
    Pre-Clinical
    RNA

    LNP- encapsulated mRNA encoding RBD

    Fudan University/ Shanghai JiaoTong University/RNACure Biopharma
    COVID-19

    Pre-Clinical
    RNA
    Replicating Defective SARS- CoV-2 derived RNAs
    Centro Nacional Biotecnología (CNB-CSIC), Spain
    COVID-19
    Pre-Clinical

    RNA

    LNP- encapsulated mRNA
    University of Tokyo/ Daiichi-Sankyo

    COVID-19
    Pre-Clinical
    MERS

    RNA
    Liposome- encapsulated mRNA
    BIOCAD
    COVID-19
    Pre-Clinical
    RNA
    mRNA
    China CDC/Tongji University/Stermina
    COVID-19
    Pre-Clinical

    RNA
    mRNA
    Arcturus/Duke-NUS
    COVID-19
    Pre-Clinical

    multiple candidates
    RNA
    mRNA
    BioNTech/Fosun Pharma/Pfizer
    COVID-19
    Pre-Clinical

    RNA
    saRNA
    Imperial College London
    COVID-19
    Pre-Clinical

    EBOV; LASV, MARV, Inf (H7N9), RABV

    RNA
    mRNA
    Curevac
    COVID-19
    Pre-Clinical
    RABV, LASV, YFV; MERS, InfA, ZIKV, DengV, NIPV

    VLP
    Virus-like particle, based on RBD displayed on virus-like particles
    Saiba GmbH
    COVID-19
    Pre-Clinical
    VLP
    Plant-derived VLP
    Medicago Inc.
    COVID-19

    Pre-Clinical
    Flu, Rotavirus, Norovirus, West Nile virus, Cancer
    VLP
    ADDomerTM multiepitope display
    Imophoron Ltd and Bristol University’s Max Planck Centre
    COVID-19
    Pre-Clinical
    Unknown
    Unknown
    ReiThera

    COVID-19
    Pre-Clinical
    Unknown
    Unknown
    BioNet Asia

    COVID-19
    Pre-Clinical
    Unknown
    Unknown
    ImmunoPrecise

    COVID-19

    Pre-Clinical
    Unknown
    Unknown
    MIGAL Galilee Research Institute
    COVID-19
    Pre-Clinical
  8. [verwijderd] 13 april 2020 12:57


    Unknown
    Unknown
    Doherty Institute
    COVID-19
    Pre-Clinical
    Unknown
    Unknown
    Tulane University
    COVID-19
    Pre-Clinical

    DISCLAIMER:
    These landscape documents have been prepared by the World Health Organization (WHO) for information purposes only concerning the 2019-2020 global of the novel coronavirus. Inclusion of any particular product or entity in any of these landscape documents does not constitute, and shall not be deemed or construed as, any approval or endorsement by WHO of such product or entity (or any of its businesses or activities). While WHO takes reasonable steps to verify the accuracy of the information presented in these landscape documents, WHO does not make any (and hereby disclaims all) representations and warranties regarding the accuracy, completeness, fitness for a particular purpose (including any of the aforementioned
    purposes), quality, safety, efficacy, merchantability and/or non-infringement of any information provided in these landscape documents and/or of any of the products referenced therein. WHO also disclaims any and all liability or responsibility whatsoever for any death, disability, injury, suffering, loss, damage or other prejudice of any kind that may arise from or in connection with the procurement, distribution or use of any product included in any of these landscape documents.
  9. [verwijderd] 13 april 2020 15:43
    quote:

    Twin schreef op 13 april 2020 13:33:


    Dank u break up voor uw antwoord


    Graag gedaan overigens zal bij de buren de CEO zijn hart overslaan mocht het gebruikt worden, begrijp mij niet verkeerd, dat zou de prijs van Ruconest om zeep hebben geholpen.
    Want als medicatie tegen Corona daar zit deze niet op te wachten is mijn overtuiging.
    Maar hij kan denk ik gerust zijn.
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