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NEWS : ESPERITE ACQUIRES INKARYO

39 Posts
Pagina: 1 2 »» | Laatste | Omlaag ↓
  1. [verwijderd] 19 maart 2015 07:26
    ESPERITE (ESP) ACQUIRES INKARYO, US START-UP SPECIALISED IN BIOINFORMATICS FOR GENETIC DIAGNOSTICS AND MOLECULAR CYTOGENETIC TESTS

    ESPERITE's strengthens its diagnostic tests to top the market with eKaryotype, electronic whole-genome Karyotype test.

    Esperite welcomes Xitong li, Ph.D., ex-Verinata Illumina Director of Bioinformatics



    Geneva, Switzerland - 19 March 2015

    ESPERITE announces the acquisition of InKaryo, the US-based company from Silicon Valley specialized in cytogenetic analysis through next generation sequencing (NGS). ESPERITE incorporates Xitong Li, Ph.D., -former Director of Bioinformatics at Verinata Illumina- to its expert team to advance molecular diagnostics and translate breakthrough technology into high quality wider scope and affordable genetic tests to top the predictive and personalized medicine sector. This acquisition avails ESPERITE the most advanced bioinformatics analytical processing of NGS data for the detection and quantification of chromosomal numerical and structural abnormalities, improving and expanding the performance and resolution of the entire present and future genetic tests portfolio. Pursuant to the transaction, ESP will acquire the Inkaryo shares at a purchase price of USD260,000, and assume its obligations under its 2-year 6% USD 280,000 convertible bond due May 2015. Except for a small USD40,000 cash payment on completion, ESP is entitled to pay the purchase price in shares. If it elects to do so, the Sellers collectively will receive 73,530 new ESP shares. ESP is entitled to convert the convertible bond in ESP shares at a conversion price of EUR2.99.

    ESPERITE will top the genetic tests market by analysing the entire genome for all chromosomal and sub- chromosomal abnormalities applicable to pre-natal genetic analyses, identification of causes of genetic disorders and high resolution tumor characterization.

    ESPERITE is proud to incorporate Xitong Li, Ph.D., to its team to drive the company's scientific development. With a distinguished career in bioinformatics in the US spanning over 15 years, Xitong Li brings his experience in architecting solutions and delivering biomarker and genomic-based clinical diagnostic products to Genoma and ESPERITE. Before founding InKaryo, he was the Director of Bioinformatics at Verinata Illumina, Associate Director of Bioinformatics for Genomic Health, and contributed to Ingenuity Systems and Novartis Pharmaceuticals Corp. He received his Ph.D. in Cellular, Molecular and Developmental biology from the University of Rochester.

    eKaryotype, higher resolution, higher accuracy than CGH, CMA or Microarrays

    Through the examination of chromosomes in a sample, the karyotype test can identify causes of genetic disorders. InKaryo's revolutionary eKaryotyping generates a digital ideograph of high resolution and high accuracy using NGS in combination with the most advanced bioinformatics processes. ESPERITE will utilize eKaryotype to detect cytogenetic aberrations with higher accuracy and higher resolution across the whole genome at a cost lower than all major CGH or CMA microarrays commercially available.

    InKaryo's NGS experimental protocol and proprietary bioinformatics analysis cover the full genome evenly with highly specific and accurate digital sequence output, reinventing karyotyping with a leap in quality yet at a fraction of the cost comparing array based comparative genomic hybridization (aCGH), or chromosomal microarray analysis (CMA). Sequencing will be to higher coverage and the test will look for large deletions and duplications uses advanced bioinformatics to find the large deletions and duplications.

    Market size for cytogenetic karyotype

    The global molecular diagnostics market has been estimated at 4.5 billion USD in 2013, and the global cytogenetics market will reach 1.9 USD billion in 2019. Analysts forecast growth in the global molecular cytogenetics Market at a CAGR of 23.51% over the period 2013-2018.

    The global newborn screening market was valued at an estimated $438.9 million in 2013 and is expected to reach $819.6 million by 2019, growing at a CAGR of 11.0% between 2013 and 2019, fuelled by technological advancements, government support, and expanding panel of newborn diseases.

    The perinatal Genetic Testing market is expected to continue its fast-paced growth posting a CAGR of 31.91 percent for the period 2014- 2019

    The global market for prenatal diagnostics in 2010 was USD 5.35 billion and it is expected to grow with a CAGR of 4.35% and generate revenues of USD 5.89 billion by 2018. The U.S. and Europe are the market leaders in prenatal diagnostics.

    Preimplantation genetic diagnosis (PGD) screening of embryos for aneuploidy will be a major growth application since approximately half of the cases of embryonic loss within assisted reproductive technology (ART) are associated with aneuploidy. Of the total PGD testing in the U.S., 78% search for chromosomal abnormalities such as aneuploidy, translocations, and gender determination. The remaining 22% of PGD testing search for single-gene mutations and human leukocyte antigen (HLA) typing. In the long term, prenatal testing and PGD will be in demand as women delay motherhood.

    Xitong Li, founder of InKaryo: "We are committed to make high accuracy diagnostics affordable to people around the world by leveraging the next generation sequencing platform. We are excited to join ESPERITE to make our bioinformatics solutions widely available through GENOMA's genomic tests and develop its new products, setting new standards of healthcare."

    Frederic Amar, CEO of ESPERITE: "The acquisition of InKaryo and its strong background strengthens our strategy to drive scientific development and our ability to create a solid pipeline of genetic tests"



    About ESPERITE

    ESPERITE group, listed at Euronext Amsterdam and Paris, is a leading international company in regenerative and predictive medicine since 2000, operational in nearly 40 countries with a network of 6,000 clinics worldwide. ESPERITE serves clients in its state-of-the-art lab facilities in Geneva coupled with ultra-modern processing and storage facilities in Belgium, Switzerland, Germany, Dubai, South Africa and Portugal. Its family stem cell bank, CryoSave, stores 280,000 samples from umbilical cord blood and cord tissue.

    To learn more about the ESPERITE group, or to book an interview with CEO Frederic Amar: +31 575 548 998 - ir@esperite.com or visit the websites at www.esperite.com and www.genoma.com.



    About InKaryo

    InKaryo was founded by a group of scientists with expertise in all major next generation sequencing platforms (454, SOLiD, GAII, HiSeq, MiSeq, Ion PGM, Ion Proton, and Complete Genomics), sequencing reagents, sequencing applications, genomic diagnostics, and bioinformatics from our work at Genomic Health, Life Technologies, Ion Torrent, Illumina, and Complete Genomics.
  2. patrick 22 19 maart 2015 07:44
    Nieuws



    Esperite
    2,900 ( 18/03 )

    Esperite koopt Amerikaans bedrijf

    19-03-2015 07:39:00

    AMSTERDAM (Dow Jones)--Esperite nv (ESP.AE) heeft InKaryo gekocht, een Amerikaans bedrijf dat zich specialiseert in cytogenetica, het in kaart brengen van DNA.

    Esperite betaalt $280.000 voor de aandelen van InKaryo en neemt ook een converteerbare obligatie over van $280.000 die tegen een conversiekoers van EUR2,99 kan worden uitgeoefend.

    Van het overnamebedrag wordt $40.000 in contanten betaald, en de rest kan Esperite met aandelen financieren. Dat zou betekenen dat de overname 73.530 aandelen Esperite gaat kosten.
  3. forum rang 10 DeZwarteRidder 19 maart 2015 07:50
    quote:

    patrick 22 schreef op 19 maart 2015 07:44:

    Nieuws

    Esperite
    2,900 ( 18/03 )

    Esperite koopt Amerikaans bedrijf

    19-03-2015 07:39:00

    AMSTERDAM (Dow Jones)--Esperite nv (ESP.AE) heeft InKaryo gekocht, een Amerikaans bedrijf dat zich specialiseert in cytogenetica, het in kaart brengen van DNA.

    Esperite betaalt $280.000 voor de aandelen van InKaryo en neemt ook een converteerbare obligatie over van $280.000 die tegen een conversiekoers van EUR2,99 kan worden uitgeoefend.

    Van het overnamebedrag wordt $40.000 in contanten betaald, en de rest kan Esperite met aandelen financieren. Dat zou betekenen dat de overname 73.530 aandelen Esperite gaat kosten.
    Het over te nemen minibedrijfje is duidelijk mislukt, anders zouden ze niet te koop zijn voor dit bedrag.
    Op z'n minst moet er heel veel geïnvesteerd worden om hier enige omzet te generen.

    Een grote emissie voor Esperite is onvermijdelijk.
  4. Vitavita 19 maart 2015 07:56
    quote:

    DeZwarteRidder schreef op 19 maart 2015 07:50:

    [...]

    Het over te nemen minibedrijfje is duidelijk mislukt, anders zouden ze niet te koop zijn voor dit bedrag.
    Op z'n minst moet er heel veel geïnvesteerd worden om hier enige omzet te generen.

    Een grote emissie voor Esperite is onvermijdelijk.
    Indien, dan is daar toch niets mis mee, een goede ondernemer ziet kansen, en daar hoort financiering bij......

    Het gaat om ROI !

    Bekend voorbeeld: ASML
  5. [verwijderd] 19 maart 2015 07:57
    eKaryotype 3000 Services (for research use only)
    Our eKaryotype 3000 services include genomic DNA sequencing followed by our proprietary bioinformatics analysis to detect whole chromosome aberration (aneuploidy) or sub-chromosomal aberration with high accuracy. Please take a look our technology and how it compares to other platforms. The research applications include research studies in the following fields:
    Down syndrome, Turner syndrome, Patau syndrome, Edwards syndrome, Klinefelter syndrome, Mosaic Turner syndrome, Mosaic Down syndrome;
    Developmental, neurological, or mental disorders related to sub-chromosomal aberrations such as DiGeoge syndrome, Angelman syndrome, Prader-Willi syndrome, Cri-du-Chat syndrome, and autism spectrum disorders.
    Cancer or tumor samples due to chromosomal aberration in cells. We are especially good at differentiating the cytogenetics of tumor cells mixed with normal cells.
    Chromosome and cytogenetics aberration detection in fetal DNA presented in the mix of maternal DNA from mother's blood or plasma (non-invasive yet highly accurate detection).

    Next Generation Sequencing Services
    We provide next generation sequencing services at very competitive pricing with high throughput of reads at very fast turn around time (about 3 business days with sample prep and bioinformatics included) with Ion Proton sequencing machine with typical sequence read outputs around 60 million to 85 million.

    Contract Research Services (CRS)
    InKaryo also accepts contracts for research testing. Our scientists are experienced at every single steps of next generation sequencing. Our world class bioinformatics team have solved several most challenging computational problems for genomic diagnostics. Together, we provide the best solutions for big pharmaceuticals and small biotechs. Below is a list of our exemplary sequencing based services:
    High resolution high accuracy cytogenetics mapping (eKaryotyping)
    High accuracy sequencing based CNV detection at a competitive cost
    Cytogenetic study of mixed cell populations
    Mosaicism study (study of genomic multitudes)
    Mitochondria related study
    Veterinary study
    RNA co-expression module
    RNA cancer biomarker screening
    SNP and mutation study
    Bioinformatics sequencing analysis (propriertary or customized)
    Environmental bacterial metagenome sequencing and bioinformatics analysis
    Please talk with us if you have any other sequencing based project.

    Bioinformatics Sequencing Data Analysis
    We are also licensing our proprietary eKaryotype bioinformatics analysis package that achieving the best results with your own sequencing data. We provide the analysis through customized server or InKaryo pre-configured Amazon cloud EC2 instance.
  6. [verwijderd] 19 maart 2015 07:59
    Xitong Li
    President

    A PhD from University of Rochester, Xitong co-founded InKaryo in April 2013 and led the development of eKaryotype product. Prior to InKaryo, Xitong was director of bioinformatics and led the sequencing analysis for prenatal verifi™ test at Verinata Health (acquired by Illumina). Prior to that, Xitong built and led bioinformatics team at Genomic Health for cancer diagnostics. He also worked at Ingenuity Systems, PPD Inc, Novartis, and MIT.
  7. forum rang 10 DeZwarteRidder 19 maart 2015 08:15
    Het is wel duidelijk geworden dat Esperite een 'testbedrijf' wil worden om allerlei testen te doen bij vooral (ongeboren) kinderen.

    Ik vrees alleen dat er maar weinig ouders zijn die deze peperdure testen kunnen betalen.
    Het zal heel erg lang duren voordat ESP hier ooit geld mee gaat verdienen.

    Het wordt waarschijnlijk een 'soort Rood Testhouse' voor ongeboren kinderen en we weten nu dat Rood na ca 30 jaar ploeteren nog steeds geen cent verdient.
  8. forum rang 10 DeZwarteRidder 19 maart 2015 08:20
    quote:

    Vitavita schreef op 19 maart 2015 07:56:

    [...]
    Het gaat om ROI !
    Inderdaad gaat het om winst maken; helaas zijn ze daar heel erg slecht in bij ESP.

    Amar is bezig met een 'buying spree' en koopt allerlei testsystemen waar hij de ballen verstand van heeft.

    Dit gaat waarschijnlijk fout aflopen (en ESP wordt zeker geen ASML!).
  9. [verwijderd] 19 maart 2015 15:07
    quote:

    DeZwarteRidder schreef op 19 maart 2015 08:20:

    [...]

    Inderdaad gaat het om winst maken; helaas zijn ze daar heel erg slecht in bij ESP.

    Amar is bezig met een 'buying spree' en koopt allerlei testsystemen waar hij de ballen verstand van heeft.

    Dit gaat waarschijnlijk fout aflopen (en ESP wordt zeker geen ASML!).

    jij loopt nu al een hele tijd alles slecht te praten.. kleine short positie opgebouwd en voorlopig de billen aan het toeknijpen? :-)

    misschien moet je analist worden. Je moet wel massa's geld verdienen aangezien jij alles als zekerheid kan brengen...
  10. [verwijderd] 19 maart 2015 15:36
    quote:

    Maeseke1 schreef op 19 maart 2015 15:07:

    [...]

    jij loopt nu al een hele tijd alles slecht te praten.. kleine short positie opgebouwd en voorlopig de billen aan het toeknijpen? :-)

    misschien moet je analist worden. Je moet wel massa's geld verdienen aangezien jij alles als zekerheid kan brengen...
    In dat geval stikt het hier van de analisten.

    Bart
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