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Aandeel Pharming Group AEX:PHARM.NL, NL0010391025

  • 0,880 19 apr 2024 15:38
  • +0,012 (+1,38%) Dagrange 0,869 - 0,889
  • 5.895.392 Gem. (3M) 6,9M

Pharming Facts II

758 Posts
Pagina: «« 1 ... 25 26 27 28 29 ... 38 »» | Laatste | Omlaag ↓
  1. forum rang 10 voda 16 mei 2022 15:11
    Zéér uitgebreid verslag..... (voor alles, zie de link onderin)

    Pharming Group N.V. (PHGUF) CEO Sijmen de Vries on Q1 2022 Results - Earnings Call Transcript
    May 15, 2022 8:11 AM ETPharming Group N.V. (PHGUF), PHAR
    Pharming Group N.V. (OTCPK:PHGUF) Q1 2022 Earnings Conference Call May 12, 2022 7:30 AM ET

    Company Participants

    Sijmen de Vries - CEO

    Jeroen Wakkerman - CFO

    Anurag Relan - Chief Medical Officer

    Conference Call Participants

    Joe Pantginis - H.C. Wainright

    Hartaj Singh - Oppenheimer & Co.

    Christian Glennie - Stifel

    Simon Scholes - First Berlin Equity

    Operator

    Hello, everyone, and welcome to the Pharming's First Quarter Results Conference Call. My name is Victoria, and I'll be coordinating your call today. [Operator Instructions]

    I'll now pass over to your host, Dr. Sijmen de Vries, CEO, to begin. Please go ahead.

    Sijmen de Vries

    Thank you very much, Victoria. Good afternoon and good morning, ladies and gentlemen. Welcome to our first quarter results call today.

    And before I go into that, I would like to go to Slide 2 and point you to the slide that shows forward-looking statements as we will be making some forward-looking statements that are based upon our current beliefs, expectations and assumptions and, of course, as you all know, things may change towards the future.

    So having said that, I would like to move to Slide 3. I'm here together with my two colleagues, Jeroen Wakkerman, our Chief Financial Officer; and Anurag Relan, our Chief Medical Officer, who will take you to the respective parts of this presentation.

    Can I have Slide 4, please? We are a well-funded business, supported by commercial sales and a growing pipeline and we focus on the treatment of rare diseases with unmet medical needs. And we can do that because RUCONEST, our lead product, is now launched in over 40 countries and recorded sales of almost $199 million in 2021. And is on its way, as you have seen from the results today, to deliver single-digit growth as we expect for 2022 over 2021.

    This is a very important part in time for the company here, because we have a near-term inflection point in our hands with the possible launch of our in-licensed compound leniolisib from Q1 2023 to treat the orphan disease APDS and that will, of course, be a significant different company after that because then we will be actually having two products in multiple geographies on and would not rely on one product that is mainly deriving sales from one geography, i.e., the United States.

    This is a rare disease, estimated according to the literature of some 1,350 patients, as you can see from this slide, and we have started at a relatively modest level with finding these patients. And we have already some 400 patients identified that could be -- become eligible for the treatment with leniolisib once approved, of course.

    We will indeed further intensify the search for these patients going forward for the remainder of the year. And we have this established specialist commercial infrastructure in US and Europe. That is why we are quite confident that we can make a commercial success out of leniolisib. And of course, we are looking as we well know from previous calls, we are intensively looking for additional late-stage opportunities to in-license and further bolster our pipeline.

    We also work on early-stage R&D products and most notably, we have last year in-licensed a potentially curative gene therapy candidate for hereditary angioedema, OTL-105, from Orchard Therapeutics and we will, of course, update you towards the future as and when important milestones have been achieved in that program.

    So we, of course, are also working on further lifecycle management opportunities for our compounds that we have in-house, which include leniolisib, which may be possible to actually be developed in additional indications other than APDS. And last but not least, we have this experienced leadership team and a strong balance sheet what can actually support our growth strategy. And we will come to that later. But it's good to say here that the current development plans and the current portfolio that we have requires no additional financing.

    So how does it look like? Please turn to Slide 5, please. How does it look like in terms of our strategy for growth? On the left-hand side, you see on this Slide 5, the commercialization of RUCONEST, which is obviously ongoing and is supporting this business.

    And as I was saying before, the launch of leniolisib will totally transfer our company -- transform our company from this one geography company to this multiple geographies and multiple product company, which is a very, very important step forward. And also we expect to be include -- we expect to be include in Japan, where we have no presence yet. And Japan, obviously, as we know, is the second biggest pharmaceutical market in the world.

    Then you see on the near-term expansion of our portfolio, as I was already alluding to that, we are actively hunting very intensively for additional in-licensing opportunities for rare disease compounds that are in late-stage development, so that we can actually establish a launch agenda beginning next year with leniolisib and following with additional compounds to be in-licensed in the subsequent years thereafter.

    But also in addition, we can continue to work on the development of C1 inhibitor and as I was saying, leniolisib, for additional indications. And then there is an interesting aspect here to being entering into this primary immune deficiency domain and starting a systematic patient finding exercise by offering genetic testing. We have access to a growing amount of genetic testing results from those patients of primary immune deficiency patients that undergo testing for APDS.

    So, we can actually start seeing and of course, this will continue to go on towards the future. We can start seeing patterns of certain mutations that are there. And therefore, we can have a, for the long term, a more directed business development efforts R&D efforts to actually address more of these primary immune deficiencies, because we believe and it's, of course, a known fact that there is about 400 genetic defects there that actually will drive -- that actually are underlying these primary immune deficiencies.

    So, we think there is a lot more to be done there and to help patients that are currently without any treatment as our patients in APDS that are waiting for leniolisib. In addition to that, of course, I was already alluding to, we're working on OTL-105, our in-licensed compound for the potential curative treatment of hereditary angioedema, and last but not least, we also have alpha-glucosidase, the new version of enzyme replacement therapy for Pompe disease, which is still a big unmet medical need.

    I would like to go to Slide 6, and you may actually go immediately to Slide 7, because I will be briefly discussing here the position of RUCONEST in the hereditary angioedema market. As we have discussed before, RUCONEST is, of course, approved for the acute treatment of hereditary angioedema attacks.

    seekingalpha.com/article/4511776-phar...
  2. forum rang 10 voda 16 mei 2022 15:18
    Deel 2:

    And that means that in this -- and I'm speaking about mainly the US market where prophylactic treatments have become more and more popular over the last couple of years, because the good news for those patients is that prophylactic treatments have significantly improved efficacy-wise and convenience-wise. But, however, means still that all prophylactic treatments are still not totally watertight.

    There is still a significant portion of patients. And if you read the published results from clinical trials, it is up to almost 50% of patients that are still suffering from breakthrough attacks under prophylaxis. Breakthrough attacks seems vary in frequency, although, but it is a still a big unmet need. And this is exactly where RUCONEST fits in because the paradigm shifts the way from prophylaxis from C1 inhibition back in the days, which was the original prophylactic treatment therapy to bradykinin and kallikrein inhibition.

    This is exactly why it is very rational to give patients a C1 inhibitor as breakthrough medication in case they have breakthrough attacks. And that is exactly what we see here, whereas traditionally we were serving only the right-hand segment here, the severance of the market, because we were late entrant and we offer a protein-replacement therapy very highly dosed.

    And people started to actually use this -- started to use our compound because they couldn't get anywhere else, that is still the core of our business, but we see an increasing number of patients being treated, albeit in a lower frequency obviously, then if you are severely affected, an increasing number of patients treating their breakthrough attacks with RUCONEST.

    And that represents here that middle part of the slide towards the left, the little dots. So in other words, we see a consistent increase of physicians prescribing RUCONEST. We see a consistent increase of patients using RUCONEST that is underlying and underpinning part of the growth that we have in the US market.

    And also on the next Slide 8, you can see that, of course, illustrated what I said just before, is that, thanks to the increasing efficacy and convenience of prophylaxis, you've seen a gradual increase of the percentage of patients that are actually using prophylactic treatments. But as you can also see, during 2021, that seems to be -- has more or less stabilized at around 70%, whereas the acute segment has almost stabilized at around 30%.

    Having said that, it is very difficult to market this -- to model this market because as I was just saying before, all patients that are using prophylaxis will have, if they, of course, adhere to their treatment plan will have breakthrough medication at hand at all time because hereditary angioedema is a very unpredictable disease and breakthrough attacks can happen at any time.

    That's why it is very difficult to actually segment this market in two parts like that, because it still means that all of these patients will have or almost all of them will have indeed the acute treatments enhanced even if they're using prophylaxis.

    So far, the hereditary angioedema market, and as I was already alluding to earlier, as this is a very historical moment for our company because we have, for the second time in our history, we have positive pivotal data for a new compound we can bring to the market. I would like to invite my colleague Dr. Anurag Relan, our Chief Medical Officer, to take you through the latest presentation on APDS and leniolisib.

    Over to you, Anurag, and over to Slide 9, I suggest.

    Anurag Relan

    Thank you, Sijmen.

    What I'd like to do today is quickly review the pathophysiology of APDS and then share with you some of the recent data that we have presented on leniolisib in treating APDS patients from the clinical studies.

    So if we can go to Slide 10, we can see the pathophysiology of APDS. And on the left side, you can see how a hyperactive PI3K delta pathway due to the genetic defect that these patients have, leads to this abnormal development of their immune system and specifically, the T and B cells. And due to that abnormal development, these patients with APDS end up with a whole slew of symptoms, many that are consistent with other primary immune deficiency.

    So first of all, of course, they get recurrent infections. So the prominent feature that APDS patients have is, what we call, lymphoproliferation. And this is just abnormal development of these -- of lymphocytes and that leads to lymphadenopathy, so swelling of the lymph node in large spleens and livers, and just abnormal lymphoid tissue throughout their body. They also have problems with autoimmunity.

    And due to the recurrent infections, they have problems in their lungs, specifically something called bronchiectasis and a whole slew of other problems, including GI and even neuro developmental problems.

    And down on the left, you see one of the other serious consequences that these patients unfortunately frequently develop, which is lymphoma. And this is due to -- it was thought to be due to that abnormal lymphoproliferation on the unchecked lymphoproliferation that these patients have.

    On Slide 11 -- I want to -- Slide 12, excuse me, I want to walk you through the studies with leniolisib. So on the left side, you can see Part 1, which was a dose-finding study and this was completed some time ago.

    And these were six patients that were treated with three different dose levels of leniolisib. Based on that study, a dose of 70-milligrams twice daily was selected for Part 2, which was the placebo-controlled study. And on the bottom-right, what you can see is the open-label extension study. Now patients from Part 1 and Part 2 were able to then enroll in the open-label extension study, which allowed us to collect long-term efficacy and safety data on the use of leniolisib.

    Today, we're going to be focusing on Part 2, but as the year moves on, we'll be receiving more data on the open-label extension study to be able to share that as well because I think this will be another important part of the data package for review will be how these patients do over the long-term. So if we go to slide -- the next slide, we can see the demographics for these patients.

    And we can see is that the patients, first of all is it's a young patient population with a median age around 20 years of age. Nearly 40% of patients belong to the age of 18 and you see the other demographics there on the slide, showing a similar frequency across the leniolisib and placebo treatment arms.

    And on the bottom-left, you can see in the overall population, again, that this is a population of patients that are quite ill with a history of numerous complications from APDS, including the ones that we just talked about lymphoproliferation, infections, the lung issues, the cytopenias, which are the autoimmune cytopenias and then, again, the issues related to the enteropathy. And on the bottom-right, you can see some of the other unique manifestations that these patients have, including neurological symptoms, and then a small proportion of these patients were even tried with off-label therapy using a drug called sirolimus.

    On the next slide, we see the first of the co-primary endpoints presented and this is a measure of the lymph node swelling and you can clearly see that the leniolisib patients had a significant decrease over placebo that was obviously statistically significant. And when we looked at -- which is called the SPD or sum of product diameters in the index lesions, we can see that this endpoint was met in a statistically significant manner.
  3. forum rang 10 voda 16 mei 2022 15:19
    Deel 3:

    On the next slide, you can see the distribution of the patients across the two treatment groups. So the leniolisib patients here are shown in blue and the placebo patients are shown in gray. And we see that the leniolisib patients had a, obviously, a significant decrease as we saw on the previous slide, but we can see the significant change from baseline in the size of these so-called index lesions across patients. And you see the placebo response as well.

    So most of the placebo patients had little change or some even had a significant increase in the size of their index lesions of these lymph nodes and then, of course, some other placebo patients that had a placebo response during this 12-week period. But you can see a clear separation of the two treatment groups both in the aggregate, when we look at the -- as we saw on the previous slide but even on a patient-by-patient basis, the clear separation across these two treatment groups.

    The other co-primary endpoint in the study was the proportion of naive B cells. And here, again, we see that the leniolisib-treated patients had a significant increase in the proportion of naive B cells versus placebo-treated patients. And naive B cells, as a reminder, are B cells that can develop and mature properly and respond to infections. So, these are important part of the maturation process.

    And in these patients, you see on the right part of the slide that they have a relatively low proportion of these B cells at baseline. But soon after treatment with leniolisib, that number increases, it stabilizes and stays at that level, whereas we see almost no change here in the naive B-cell proportion in the placebo-treated patients. So then we have both the co-primary endpoints being met in a statistically significant manner with a clear separation on the efficacy of leniolisib across these endpoints.

    On the next slide, we can see some of the other manifestations that I mentioned that APDS patients have. And that is, again, because of this abnormal lymphoproliferation, these patients have large spleens and livers. And we see that even in the course of this 12-week study, we see significant changes in leniolisib-treated patients compared to placebo-treated patients.

    The placebo-treated patients on the right panels, you see had a slight increase in the size of the spleen and liver. And you see the leniolisib-treated patients had a significant decrease. And again, these were statistically significant changes observed in this 12-week study. So quite impressive, even the short duration we see improvements in these measures of lymphoproliferation that can actually in a macro specimen, we can see that these -- the spleens and the livers are getting smaller.

    On Slide 22, we can see that leniolisib was generally well-tolerated. The safety profile across these different grades of accuracy that was similar between leniolisib and placebo in the study. There were no deaths reported. There was no discontinuation due to any adverse events and none of the serious adverse events were thought to be related to study treatment. And you see, even the frequency was lower in the leniolisib-treated arm as compared to the placebo-treated patients.

    And lastly, this is a slide I've shown before, but I think it's quite impressive. And this is now thinking back to those first six patients, those patients recall, they went on into the open-label extension study. And so this is some of their long-term data. This is actually data out to two years. We actually have data now, and we're analyzing this data for these patients out to five and in some cases, six years. So, these patients have been on therapy since the beginning of the development program.

    And you see here their IgM levels in these patients. Because of this abnormal development of their B cells, they frequently have high levels of IgM. And you can see that in these six patients, when they were treated with leniolisib, their IgM levels dropped and some of these patients weren't able to enroll in the extension study immediately and you see that in those dash lines, those patients had to discontinue for a brief period of time and there was a dosage interruption. And you see their IgM levels increase. But once those patients resumed -- and all of them were able to resume, you see those dash lines in the solid line now and those IgM levels decreasing again.

    So, I think quite a dramatic showing here of the response in IgM levels to leniolisib across these six patients. And I think probably the most important part of this is that these patients were able to, in many cases, stop the use of IV supplementation therapy. So, this is IVIG or subcutaneous IG replacement therapy that they take. Because of their immune deficiency, they were actually able to stop this because their B cells are now normally functioning.

    So, I think this is another quite a dramatic showing of the effect of leniolisib now in a longer-term setting. And as I said earlier, we're going to have data on the full patients. So now this will be, I think, 35 or 37 patients that we will have data on across this longer-term endpoint. So, we will have this data presented throughout the course of this year at some scientific symposium and meetings. And I look forward to sharing that with you.

    I'm going to end here the presentation on APDS, touching on something else on Slide 24, talking about the launch preparations in terms of finding patients. Again, APDS is a relatively recently defined disease back only in 2013 with the genetic mutation identified. And we're doing quite a bit of work now to help educate physicians about APDS and also build out a network of doctors who treat these patients who are specialists in primary immune deficiency.

    We're also doing some AI work to help identify patients based on the symptom profile that APDS patients have. And then, again, quite a bit of education, all centered around the navigate APDS program that allows for no-cost genetic testing for patients that may have APDS, so that there is no barrier for these patients to obtain a genetic diagnosis that allows them to have a specific treatment option potentially available to them in the future.

    And I will turn it back over to you, Sijmen, to walk us through some of the milestones that are coming up for the APDS program.

    Sijmen de Vries

    Thank you very much, Anurag.

    And yes, please, Slide 20. Here you see the upcoming milestones that Anurag and his team are working very hard on and other commercial teams, the commercial teams as well, of course, to prepare themselves for launches. You see here that we're working towards the, first of all, the FDA filing of the compound, followed after the summer by the EMA and British filings.
  4. forum rang 10 voda 16 mei 2022 15:20
    Deel 4:

    Then the pediatric studies are very high on the agenda to start later on during the second half of this year. As you know, there is already patients included up to until the age of 12. So, we're looking at the below-12s and it will be two pediatric studies starting in this perspective.

    As I was alluding to earlier, we're very excited about the prospect of making the move to Japan with this compound. We've had incoming requests from Japanese opinion leaders to please come to that -- to come and do a small trial. We had discussions with the Japanese authorities, and they're all very cooperative and we anticipate to be able to, this year, start that small Japanese clinical trial that is required for Japanese authorities to take this under review.

    And then, of course, we're anticipating the big moment, assuming this accelerated review by the FDA, which calls for an eight-month review cycle that we will be able to launch the product or get at a PDUFA date in the first quarter of '23, quickly followed by the US launch. And then, of course, the EMA, because it was filed later, will follow on later on with an approval.

    And then subsequently to that, in the second half of next year, we anticipate the launches in the EU countries to be rolled out across the EU. So, we're very excited about this prospect. As I was already saying, this is the route map to totally transforming the company towards a multiple company in multiple geographies, and it will take place during next year, for which we are, of course, investing very heavily.

    Speaking about investments, it's probably a good moment to switch over to our Chief Financial Officer, Jeroen Wakkerman, who's sitting next to me here. And we may actually go to Slide 21.

    Jeroen Wakkerman

    Thank you very much, Sijmen, indeed.

    On the next slide, you will see the quarterly development of revenues from RUCONEST over the last two years. And we're very pleased to say that we increased the revenue in Q1 2022 by 7% to $46.6 million. And out of that, as -- it may not be a surprise to you, most of it is from the US revenues. $45.3 million out of the $46.6 million of revenues was from the US, and that meant an increase in the country of 7% in revenue growth.

    And the increase that we saw in the number of patients was a driver of it, and it was slightly offset by tighter inventory management at larger specialty pharmacies. And -- well, as you see, the EU and rest of the world are still small, was not a strong quarter for EU and the rest of the world, but that was largely due to phasing of orders.

    The gross profit increased by 8% to $41.7 million and that was, obviously, mainly due to growth in revenues, but also the margin obviously increased with this growth number. And that is a combination of price increases and less discounts that we had to offer. So a margin improvement.

    Going two slides on, please. Yes, that one. The operating profit decreased to $2.8 million from $6.3 million last year, and that was because of the expected increase in operating expenses. The operating expense increased to $39.8 million. That's an increase of about $7 million. And that $7 million increase was a combination of several things, but half of it was because of the launch preparations for leniolisib. Other elements are increased travel activity in the U.S. post-COVID and phasing of costs. I think this is the wrong slide.

    Operator, could you put up the right slides, please?

    Operator

    The financial highlights from Q1, Slide 3.

    Jeroen Wakkerman

    Three out of five, correct. So I'm now at the -- I was saying that the operating profit decreased because of the cost increase and that was half of it was because of the announced increase in cost for the leniolisib launch preparation. Net profit decreased to $3.5 million, and that was caused obviously by the operating expense increase, as I just mentioned, but also a decrease in the finance income from last year.

    Last year, we had a big foreign exchange effect because of the euro-dollar volatility and we didn't gain as much from that this year. The cash position is still very strong. It decreased by $2.2 million, but it's still at $189.7 million, and the positive cash flows from operations amounted to positive $0.6 million. And that is obviously increasing the -- sorry, including the increased cost from the leniolisib launch preparation.

    On the next slides, we see the summary of this. Again, a profit before tax going from 12.8 to 4.2, and that was caused by underlying business gross profit, $3 million, mainly from the U.S., increased R&D expenditure because of leniolisib and some brands and that was related to phasing, a slight increase in G&A expenditure and most of the increase in marketing and sales expenditure is also due to leniolisib. Financial results from the -- that change was due to foreign exchange. Last year, financial results were $6.6 million, now $1.8 million. And therefore, we come to a profit before tax of $4.2 million.

    And on the next slide, you see some more detail on the cash and cash equivalents, again, a decrease of $2 million, and that is because of an increase in operating cash flows offset by working capital changes. We invested very little in Q1. That's expected to go up in the next few quarters. And the financing cash flow is mainly interest and lease cost. So again, a strong cash position that we will, amongst others, use for the leniolisib launch preparations.

    And with that, I would like to go to the next slide please to the outlook and hand over to Sijmen.

    Sijmen de Vries

    Thank you very much, Jeroen.

    And yes, the outlook, ladies and gentlemen, has been -- has not changed from the previous outlook that we have announced as a result of our full year results. So we continue to guide for single-digit growth in the group revenues from RUCONEST. Quarterly fluctuations in revenues are to be expected though. We still, as already stated, we are on track for Q1 '23 launch of leniolisib, subject of course to regulatory approvals.

    Company will continue to invest, as you have seen in these launch preparations and the clinical development obviously for the trials that I have outlined before. And this will of course significantly increase, as you have seen a significantly impacted profit as we have seen already. But it is also to be stated, and I said that before, that the RUCONEST cash flows will be able to fund these investments.

    So no additional financing will be needed to execute on all these things. We will also continue to invest in potential acquisitions or in-licensing of new late-stage development opportunities, as I have alluded to before, in rare diseases. And of course, if you think about in-licensing, but especially acquisitions, there may be additional financing required, which of course, can then come from our strong balance sheet, access to debt capital and access to eventually equity capital as well, certainly in the case of acquisitions.

    And last but not least, we will continue also to be able to focus on the strategic development of the company going forward and think about the additional indications, for instance, for a compound leniolisib that can be explored towards the future. And of course, our early-stage compounds will continue to be developed.

    So with that said, I would like to conclude this part of the meeting and go over to the next slide and switch the -- open the floor for questions to everybody who's attending. Thank you very much. Operator, please open the floor for the questions.
  5. forum rang 10 voda 16 mei 2022 15:21
    Deel 5:

    Question-and-Answer Session

    Operator

    Thank you. [Operator Instructions] And our first line comes from Joe Pantginis at H.C. Wainright. Please go ahead. The line open.

    Joe Pantginis

    Thanks a lot for taking the question. Hope everything is well over there. And my three questions are really focused on, I guess, what you'd call background activities. So for leniolisib, I guess, what can you describe with regard to ongoing pre-launch activities? And do you consider any of those rate-limiting at this point? And the second question is for OTL-105. Do we anticipate any preclinical news from that program over the next 12 months? And then the third question is, how would you describe the maturity of your discussions with regard to potential in-licensing?

    Sijmen de Vries

    Joe, I'll start with the first one, the pre-launch activities. I don't think there's any rate-limiting steps in there. Obviously, pre-launch activities include regulatory activities to prepare the file for submission. But also, not to forget, there is an important element here as well that the market access files for the European markets are in development.

    That's also very intense. And most importantly, I would say, the patient finding activities, as Anurag was alluding to already, they will be further increased, and that's a logical thing of course as well. As and when you gain more confidence with regards to the approvability of your file, and that is currently the case, we'll start intensifying the patient searching activities both in the U.S. and in Europe. I don't see any rate-limiting steps there at this point in time.

    So we're going full speed ahead in that respect. With regards to OTL-105, within 12 months, yes, there could be some updates I expect from OTL-105 as milestones, preclinical milestones will be achieved. So yes, I would say, within 12 months, we can actually anticipate some news on that as we progress towards getting into IND-enabling studies, I would say. So watch this space, we will of course update the market as and when there is results.

    Now with regards to in-licensing acquisition discussions, from time to time, we have indeed conversations with companies that have interesting assets for either in-licensing or acquisitions. At this point in time, some of these things are quite advanced. But of course, as you all know, and Joe, there is no news to you either, but this means nothing until such time that the ink is on paper and that there can be -- a deal can be announced.

    So we have a very, I would say, efficient business development process developed in the company because we believe it's in a very important spare point of our activities. As you know, we have developed this commercialization apparatus on both sides of the oceans and it is a very valuable asset that we have and a very important key skill set that we have onboard and expertise, and therefore, it can be leveraged.

    So we consider this as a core competency of our company, and therefore, we put a lot of emphasis on this. And it is very difficult to say, of course, as and when a deal for an in-licensing or an acquisition can be closed. But be sure that we have a lot of attention for it. I hope I answered your question, Joe?

    Joe Pantginis

    You did. I appreciate the color.

    Operator

    Our next question comes from Hartaj Singh at Oppenheimer & Co. Please go ahead.

    Hartaj Singh

    Great. Thank you for the questions, and really nice presentation. I have three questions. One is just a couple of follow-up to the previous question by Joe. In terms of planning for the leniolisib launch, Anurag and Sijmen, how is reimbursement going to work out? I mean, are you doing pharmacoeconomic modeling, for example, in cancer, the NCCN guidelines are very important? How will reimbursement preparing for that play into your plans for the launch, both in the United States and Europe? So that's 1. 2, in some of our KOL calls recently, we were told that there is a relative trend to also be at risk for this disease. Are you thinking of potential screening relative to patients in the future going forward to see if you can catch these patients early on? And then lastly, what is the size of the Japan market once or if you were to enter there with a partner?

    Sijmen de Vries

    Perhaps, I shall try first, say something about reimbursement for leniolisib. So yes, we are -- this is of course a very important aspect. We are developing the necessary files in the four months that the various European markets require. We also have of course linked in ICD-10 already in the U.S. for this -- for APDS. And yeah, so we're working basically speaking on all of those fronts. It's an important part of the pre-launch preparations. And if Anurag can add some more color to that, feel free.

    With regards to screening relatives, I would like to hand over to Anurag on this respect in a moment. The Japanese market, lastly, as we see that -- already see that without any systematic search activities, we found 6-0, 60 patients in France. We therefore have one in a million as our minimum incidence for this disease at the moment.

    Then you would say that the Japanese market would be at least 125 patients that are there or I think it's 125 million, the population of Japan. But again, one in a million is our minimum incidence rate that we think without systematic searching. And I'd hand over to Anurag. Maybe you could say something about the screening or any of the other things to give more color. Anurag?

    Anurag Relan

    So absolutely, Hartaj. The family testing is a big part of our search efforts. In fact, the program, the navigateAPDS genetic testing program, no cost program, includes the provision for family testing. So if a patient is identified, their family members are able to get tested also for no charge. We are also doing a lot of education around this front in terms of family testing. So that is currently and will continue to be a big part of the search effort for APDS patients.
  6. forum rang 10 voda 16 mei 2022 15:21
    Deel 6:

    Operator

    [Operator Instructions] And our next question comes from Christian Glennie at Stifel. Please go ahead.

    Christian Glennie

    Good afternoon, gentlemen. Thanks for taking the questions. First one on RUCONEST, please. Just wondering if you can talk a little bit more about this impact of tighter inventories in the U.S., whether that's a transitionary thing or whether that's something a bit more long-term in the sense that what might sales growth have been if there wasn't this sort of correction in the market? And would you expect a bit more normalization of buying in inventory levels through the rest of the year or was this a shift?

    Sijmen de Vries

    Yeah, that's always a difficult one, Christian, because inventory levels are part of the game, I suppose. So one quarter you have a little bit high inventory and the other part -- and the other you have a bit lower inventories.

    But we noticed that this time there was a decrease in inventories because we obviously keep very good track of it because it's only a few of these specialist pharmacies that we're dealing with here. And this -- I don't think there's any sort of systematic thing here, but it was noticeable here that it was lower. Hence, we basically reported it as we should be of course. So there's nothing behind that.

    As I was saying, we still are confident about the RUCONEST business because we see an increasing number of patients and an increasing number of physicians prescribing it. We see the necessity and everybody seems to be getting to see this necessity that it is good to have a C1 inhibitor onboard as breakthrough therapy when you block the bradykinin kallikrein in them, X axis by means of your prophylaxis, which was of course, a very long-term thing when people have to switch from C1 inhibition and bradykinin kallikrein inhibitious breakthrough to the other way around. That takes a while. That's a slow process, but it continues to go forward as we were predicting, I would say, back in the days, and as we see now developing in the market. I think that's all I can say about this at the moment, Christian.

    Christian Glennie

    Turning to leniolisib then, couple of things. Firstly on the patients identified and some of the numbers there. I think you said now 400, previously, that was at 350, but I can't remember whether that was the start of the year, whether you're sort of -- you added about 50 patients in the quarter or something like that. Is that about right? And then that implies about 30% -- you found about 30% of the patients in the U.S. and Europe. I mean, how high do you think the diagnosis rate could go here?

    Sijmen de Vries

    Well, as I was saying before, we are already quite confident about the fact that we could see 1% of the population having this disease. With further intensification of the activities in the market, i.e., we will be sending more people, more colleagues into the market to actually start going to these immunology clinics and trying to find these patients that are already being treated, but that are not diagnosed.

    So in other words, we expect of course that this growth will at least continue or maybe further accelerate. But we're certainly going to intensify further the activities because we have of course gained more confidence over the last months in leniolisib being an approvable product. And that goes on both sides of the ocean. I would say, it's happening in the U.S. and it's happening in Europe as well. Although in Europe, as we know, slightly different organized.

    Obtaining genetic testing is a little bit easier and often reimbursed. But there again, we're working with the specialist centers of excellence of these immune -- primary immune deficiencies towards analyzing these patients and their families, of course, that's an important aspect as well. I hope I answered your question?
  7. forum rang 10 voda 16 mei 2022 15:22
    Christian Glennie

    Turning to leniolisib then, couple of things. Firstly on the patients identified and some of the numbers there. I think you said now 400, previously, that was at 350, but I can't remember whether that was the start of the year, whether you're sort of -- you added about 50 patients in the quarter or something like that. Is that about right? And then that implies about 30% -- you found about 30% of the patients in the U.S. and Europe. I mean, how high do you think the diagnosis rate could go here?

    Sijmen de Vries

    Well, as I was saying before, we are already quite confident about the fact that we could see 1% of the population having this disease. With further intensification of the activities in the market, i.e., we will be sending more people, more colleagues into the market to actually start going to these immunology clinics and trying to find these patients that are already being treated, but that are not diagnosed.

    So in other words, we expect of course that this growth will at least continue or maybe further accelerate. But we're certainly going to intensify further the activities because we have of course gained more confidence over the last months in leniolisib being an approvable product. And that goes on both sides of the ocean. I would say, it's happening in the U.S. and it's happening in Europe as well. Although in Europe, as we know, slightly different organized.

    Obtaining genetic testing is a little bit easier and often reimbursed. But there again, we're working with the specialist centers of excellence of these immune -- primary immune deficiencies towards analyzing these patients and their families, of course, that's an important aspect as well. I hope I answered your question?

    Christian Glennie

    And then I just wondered if you had yet done any survey work or market research around the 400 or so patients that you managed to identify and their physicians, I guess, their doctors. What percentage of those would indicate that they would prescribe leniolisib sort of standard survey work you might do?

    Sijmen de Vries

    No, there is -- if Anurag has something to add, obviously he can, but I'll try to answer this first. One of the things is of course the patients that are eligible for treatment are currently to 12, if the product gets approved from the current douche, of course, there is 12 years and older. So we will have to -- for the pediatric study, we have to wait for the periodic studies of course for the pediatric population. That's one thing of course.

    But as far as I know and see from patient narratives and so on, patients that are eligible for treatment are all very interested in getting the treatment as are the doctors because there's simply nothing there. And Anurag can put more color on it because he's been sort of visiting these conferences where, amongst others, the data was presented and he picked up a lot more on that background. Maybe you can give some color there, Anurag, to what you think about the willingness to prescribe interest in the treatment?

    Anurag Relan

    Absolutely. The data has been well received so far from when we presented it actually in our conferences, both in the U.S. as well as in Europe. And the feedback that we're getting from physicians has been quite positive that these data are impressive, including some of the long-term data that I showed today, especially the ability for these patients to potentially be able to stop IG replacement therapy. This is something that was viewed quite positively by the immunology community.

    So I think the -- when they see these data and they see their patients, the feedback that we're getting is again this -- if leniolisib was available, this would be something they would certainly consider for these patients.
  8. forum rang 10 voda 16 mei 2022 15:23
    Laatste deel:

    Christian Glennie

    And then if I can, just finally on the regulatory side with leniolisib. Is it possible to say at this stage whether you might expect an advisory committee as part of the review process? And then, is it your understanding that this indication and leniolisib and the approval would be applicable or appropriate for a priority review voucher? And if so, is that a voucher that would be in Pharming's hands or in Novartis' hands or rights to have priority review voucher?

    Sijmen de Vries

    Maybe I can hand over to Anurag first for the regulatory question.

    Anurag Relan

    So in terms of the advisory committee, this is -- we're just beginning the process in terms of -- we haven't actually filed yet, so FDA will notify us after they review the application whether they determine whether advisory committee is necessary.

    So we'll leave that in FDA's capable hands. Of course, we're preparing in case that an advisory committee is needed, we would be ready for that. But this was really FDA's decision based on their review of the data, and they haven't received the file yet. So they don't have any determination on that yet. And then I think, Sijmen, you wanted to make a comment about the priority review voucher.

    Sijmen de Vries

    Christian, we do think that we will be qualifying for that. And in case such a priority voucher will be granted, then obviously, that is in -- I think, let me think about the contract precisely, that will be in the hands of Novartis. But we have agreed a certain split of the value of such voucher between Novartis and us commensurate to I think the investment in the compound as and when the compound gets approved. So yes, it is there. And yes, there is some value in it for Pharming, but it's an undisclosed amount as you may appreciate.

    Operator

    [Operator Instructions] And our next question comes from Simon Scholes at First Berlin Equity. Please go ahead.

    Simon Scholes

    Yes, hello. Thanks for taking my questions. I've just got one. I was just wondering when we might get the next piece of news flow on the Pompe program?

    Sijmen de Vries

    That's a good question, Simon. I would say that later on in the year, we will definitely. But it will be more towards the end of the year, we will definitely give some more updates on the Pompe program. But again, it is not one of the main value drivers, as you could appreciate, because it's in preclinical, right? That's -- and in this comp of course, that's why.

    Operator

    Perfect. Thank you so much for answering questions. At this time, there are no further questions. And now I would like to pass it back over to Sijmen for any final remarks.

    Sijmen de Vries

    Thank you very much, Victoria. Yes, ladies and gentlemen, thanks for attending this. As you have seen, we delivered on our -- on the first part of the single-digit growth expectations that we have for 2021. We also have informed you and are executing on increasing the investments ahead of the launch of leniolisib, which of course, will transform our company significantly towards a multiple product company with multiple markets where we get our revenues from. So we significantly derisk our company going forward.

    You all saw also that we are very much hunting for additional late-stage assets because we have the balance sheet to do this and we have access to debt capital, and eventually, in the case of acquisitions even for equity capital as well. And last but not least, it's very important to note here that executing on our plans on the current portfolio does not require additional financing that we can see.

    So with that said, I would like to thank you for your attention. And I would like to look forward to updating you again on the progress of the company as and when we have our first half results, which will be in the first week of August, if I remember well. Thank you very much, and good bye.
  12. forum rang 10 voda 6 juni 2022 07:15
    Pharming pas overnameprooi zodra pijplijn is gevuld

    20 mei 2022

    Dat de toonzetting binnen een jaar flink kan veranderen, bewees Pharming tijdens de aandeelhoudersvergadering van 18 mei jongstleden. Terwijl vorig jaar Pharming zich vooral wilde presenteren als jager in plaats van prooi, was topman Sijmen de Vries inmiddels een stuk realistischer in zijn ambities

    In de tussentijd is verder onderzoek naar patiëntvriendelijker toedieningswijzen van Ruconest – het enige medicijn dat Pharming op de markt heeft – stopgezet, net als studies met betrekking tot covid. Ook lijkt Pharming minder voortvarend en optimistisch in de mogelijke inzet van de onderliggende werking van Ruconest op andere ziektes, zoals zwangerschapsvergifting. Tot slot gaat de bouw van geplande fabriek voor de productie van Ruconest niet door, maar verlengt Pharming de samenwerking hiervoor met Sanofi. Dat doet nu pijn, want er moest 5,4 miljoen dollar worden afgeschreven, maar Pharming vermijdt hiermee verdere investeringen van ruim 40 miljoen euro.

    Slank Pharming onaantrekkelijke overnameprooi
    Een afgeslankt Pharming is niet aantrekkelijk als overnamekandidaat, aldus De Vries in de aandeelhoudersvergadering na vragen van de VEB. Met slechts Ruconest als cashcow in een overvolle markt (HAE, een zeldzame zwellingsziekte) kan Pharming weliswaar voorlopig nog positieve kasstromen genereren, maar stevige groei zit er niet meer in.

    Dat gaat volgens de ceo veranderen als Leniolisib – een middel tegen een extreem zeldzame immuundeficiëntieziekte waarvan Pharming eerder de verkooprechten had gekocht – volgend jaar echt op de markt komt. Medicijnen tegen zeldzame ziekten kunnen financieel zeer aantrekkelijk zijn, zeker als er nauwelijks concurrentie is. De Vries verwacht dan ook dat Leniolisib veel groter kan worden dan Ruconest.

    Veel trouwe aandeelhouders zullen terecht teleurgesteld zijn; ruim 14 procent van de stemmen verleende zelfs geen decharge aan bestuur en commissarissen. De verwachtingen over allerlei eerdere initiatieven van Pharming bleken veel te hoog, wat ook zichtbaar is het koersverloop van het aandeel.

    Toch kunnen beleggers hopen op betere tijden als Leniolisib inderdaad een succes blijkt. Een Pharming met Ruconest als cashcow en Leniolisib als groeimotor wordt niet alleen steeds winstgevender, maar heeft daarnaast een lager risicoprofiel en zal ook veel hoger worden gewaardeerd. Zowel op Euronext en de Nasdaq, maar ook door potentiële jagers.

    www.veb.net/artikel/08641/pharming-pa...
  14. forum rang 10 voda 1 augustus 2022 07:07
    Operational updates 1 augustus

    Pharming Group Receives Accelerated Assessment in Europe for leniolisib for the Treatment of Rare Immunodeficiency, APDS

    Pharming Group N.V. announces that the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) has granted an accelerated assessment for the Marketing Authorisation Application (MAA) for leniolisib. Leniolisib has been studied for the treatment of activated PI3K delta syndrome (APDS), a rare primary immunodeficiency, in adults and adolescents age 12 or older in the European Economic Area (EEA). Pharming is on track and plans to submit its MAA for leniolisib to the EMA in October 2022.

    “The acceptance of an accelerated regulatory review for leniolisib underlines the high unmet need for patients with APDS, with the product potentially being the first approved treatment for this rare disease."

    - Anurag Relan - Chief Medical Officer

    Voor meer, zie link:

    www.pharming.com/sites/default/files/...
    (Nederlands)

    www.pharming.com/sites/default/files/...

    (Engels)
  15. forum rang 10 voda 1 augustus 2022 07:17
    Positief nieuws Pharming in Europa
    Versnelde beoordeling voor leniolisib.

    (ABM FN-Dow Jones) Pharming Group krijgt een versnelde beoordeling in Europa voor leniolisib ter behandeling van een zeldzame aandoening aan het immuunsysteem APDS. Dit maakte het biotechbedrijf maandag voorbeurs bekend.

    Het Comité voor geneesmiddelen voor menselijk gebruik van het Europees Geneesmiddelenagentschap EMA heeft een versnelde beoordeling van de vergunningaanvraag voor toelating tot de markt verleend.

    Hierdoor zal de beoordeling niet 210 maar 150 dagen duren, aldus Pharming.

    Pharming ligt naar eigen zeggen op schema voor indiening bij de EMA van de vergunningaanvraag voor leniolisib in oktober 2022.

    "De acceptatie van een versnelde beoordeling door het EMA voor leniolisib onderstreept de grote onvervulde behoefte van patiënten die lijden aan APDS. Het product wordt mogelijk de eerste goedgekeurde behandeling voor deze zeldzame aandoening", zei Chief Medical Officer Anurag Relan in een toelichting op het nieuws.

    Door: ABM Financial News.

    info@abmfn.nl

    Redactie: +31(0)20 26 28 999
  16. forum rang 10 voda 2 augustus 2022 07:48
    Pharming meldt nieuwe ICD-10 code voor APDS.
    Een zeldzame aandoening aan het immuunsysteem.

    (ABM FN-Dow Jones) Pharming voegt een nieuwe diagnosecode toe aan de International Classification of Diseases, die vanaf 1 oktober van kracht wordt. Dit maakte het biotechbedrijf dinsdag bekend.

    Het gaat om de diagnosecode, D81.82 -- Activated Phosphoinositide 3-kinase Delta Syndrome (APDS) voor het rapporteren van gevallen van geactiveerd fosfoinositide 3-kinase delta syndroom (APDS), een zeldzame primaire aandoening aan het immuunsysteem.

    De toewijzing van de ICD-10-CM-code stelt artsen, 'payers' en verzekeraars in de Verenigde Staten voor het eerst in staat om een diagnose van APDS toe te voegen aan de medische dossiers van patiënten, wat hen zal helpen in contact te komen met onderzoekers die de prevalentie en het beloop van de ziekte bestuderen.

    Bovendien kan de nieuwe ICD-10-CM-code door een specifieke diagnose toe te kennen, helpen bij het vaststellen van de medische noodzaak bij individuele patiënten, waardoor hun toegang tot relevante zorg via Amerikaanse ziektekostenverzekeringen wordt verbeterd.

    Door: ABM Financial News.

    info@abmfn.nl

    Redactie: +31(0)20 26 28 999
  18. forum rang 10 voda 4 augustus 2022 07:04
    Pharming Group reports financial results for the first half of 2022

    Pharming Group N.V. presents its preliminary (unaudited) financial report for the first six months of 2022 ended June 30, 2022.

    Hier alle cijfers: (in NL)

    www.pharming.com/sites/default/files/...

    In Engels:

    www.pharming.com/sites/default/files/...
  19. forum rang 10 voda 4 augustus 2022 07:11
    Flinke winststijging Pharming
    Halfjaaromzet met 4 procent omhoog.

    (ABM FN-Dow Jones) Pharming Group heeft in de eerste helft van 2022 meer omzet en vooral meer winst geboekt. Dit bleek donderdag uit cijfers van het biotechbedrijf.

    De omzet van Pharming steeg in de eerste zes maanden van dit jaar met 4 procent naar 96,8 miljoen dollar, "geholpen door meer artsen die Ruconest voorschreven en een toename van het aantal patiënten", aldus Pharming.

    De operationele winst steeg met 20 procent op jaarbasis naar 20,6 miljoen dollar en de nettowinst kwam bijna 5 miljoen dollar hoger uit op 19,2 miljoen dollar.

    Aan het einde van juni had Pharming nog 191 miljoen dollar in kas.

    Pharming heeft de afgelopen periode kritisch naar de eigen pijplijn gekeken en besloten om de ontwikkeling van rhC1INH voor acuut nierfalen (AKI) en pre-eclampsie stop te zetten. Het biotechbedrijf wil zich concentreren op de verkoop van Ruconest en de lancering van leniolisib.

    Het onderzoek naar de ontwikkeling van een alfa-glucosidasetherapie van de volgende generatie voor de behandeling van de ziekte van Pompe loopt nog.

    Leniolisib wordt vermoedelijk in de eerste helft van 2023 in de VS goedgekeurd en geïntroduceerd. In de tweede helft zouden Europa en het Verenigd Koninkrijk moeten volgen.

    Wel blijft Pharming kijken naar mogelijkheden om nieuwe activa in de late fase van klinische

    ontwikkeling door in-licentiëring dan wel een overname te verwerven. Hiervoor kan Pharming onder meer terugvallen op zijn kaspositie, eventueel aangevuld met financiering via de kapitaalmarkt.

    Outlook

    "De verwachte eencijferige groei van de groepsomzet Ruconest-verkopen, gedreven door de VS en uitgebreide EU-markten, is mogelijk onderhevig aan zakelijke beperkingen in verband met de COVID-19-pandemie", meldde Pharming.

    Door: ABM Financial News.

    info@abmfn.nl

    Redactie: +31(0)20 26 28 999
  20. forum rang 10 voda 4 augustus 2022 09:47
    Update: Flinke winststijging Pharming
    Halfjaaromzet met 4 procent omhoog.

    (ABM FN-Dow Jones) Pharming Group heeft in de eerste helft van 2022 meer omzet en vooral meer winst geboekt. Dit bleek donderdag uit cijfers van het biotechbedrijf.

    De omzet van Pharming steeg in de eerste zes maanden van dit jaar met 4 procent naar 96,8 miljoen dollar, "geholpen door meer artsen die Ruconest voorschreven en een toename van het aantal patiënten", aldus Pharming.

    De operationele winst steeg met 20 procent op jaarbasis naar 20,6 miljoen dollar en de nettowinst kwam bijna 5 miljoen dollar hoger uit op 19,2 miljoen dollar.

    Aan het einde van juni had Pharming nog 191 miljoen dollar in kas.

    Pharming heeft de afgelopen periode kritisch naar de eigen pijplijn gekeken en besloten om de ontwikkeling van rhC1INH voor acuut nierfalen (AKI) en pre-eclampsie stop te zetten. Het biotechbedrijf wil zich concentreren op de verkoop van Ruconest en de lancering van leniolisib.

    Het onderzoek naar de ontwikkeling van een alfa-glucosidasetherapie van de volgende generatie voor de behandeling van de ziekte van Pompe loopt nog.

    Leniolisib wordt vermoedelijk in de eerste helft van 2023 in de VS goedgekeurd en geïntroduceerd. In de tweede helft zouden Europa en het Verenigd Koninkrijk moeten volgen.

    In een toelichting aan ABM Financial News benadrukte CEO Sijmen de Vries de indiening van de aanvraag voor versnelde markttoegang voor leniolisib bij de Amerikaanse FDA. De toezichthouder heeft nu 60 dagen om de indiening van Pharming te bevestigen. Rond 27 september wordt dit duidelijk. En vervolgens zal de FDA dan binnen 6 maanden een oordeel vellen of het product op de Amerikaanse markt mag komen. "Dat is nog mooi in het eerste kwartaal", aldus De Vries.

    Indien deze termijnen allemaal worden gehaald, dan vinden de eerste verkopen van leniolisib in de VS nog voor het einde van het tweede kwartaal in 2023 plaats.

    Verder blijft Pharming kijken naar mogelijkheden om nieuwe activa in de late fase van klinische ontwikkeling door in-licentiëring dan wel een overname te verwerven. Hiervoor kan Pharming onder meer terugvallen op zijn kaspositie, eventueel aangevuld met financiering via de kapitaalmarkt.

    "We zijn nog steeds op jacht", aldus De Vries, die meent dat het een goede tijd is om met een gevulde kas te jagen op overnameprooien.

    Outlook

    "De verwachte eencijferige groei van de groepsomzet Ruconest-verkopen, gedreven door de VS en uitgebreide EU-markten, is mogelijk onderhevig aan zakelijke beperkingen in verband met de COVID-19-pandemie", meldde Pharming.

    Update: om meer informatie en toelichting De Vries toe te voegen.

    Door: ABM Financial News.

    info@abmfn.nl

    Redactie: +31(0)20 26 28 999
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