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Home  /  Forum  /  BioPharma  /  Northwest Biotherapeutics Inc. (NWBO.OB)

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Northwest Biotherapeutics Inc. (NWBO.OB)

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  1. [verwijderd] 15 juli 2010 21:07
    Stock : BiomedReports (NWBO)
    Quote : $ 1.241 0.406 (+48.62%)

    Best Cancer Vaccine? Answer May Surprise Investors.
    According to a newly published report, Northwest Biotherapeutics' (OTCBB: NWBO) DCVax® may be poised to surpass Dendreon's product in the field of vaccine based cancer treatments. Speculators have begun to rush back to pick up shares of NWBO just as sector darling Dendreon Corporation has seen its shares lose 44% of their value after news that Dendreon can only make enough of their recently approved prostate cancer drug to treat about 2% of eligible patients.

    In a featured article today, BioMedReports lists several reasons for the rise of DCVax®.

    First factor: The quality and characteristics of the antigens used by both companies in their vaccines

    What matters here according to representatives at NWBO is Dendreon's target antigen is not expressed on all prostrate cancers. They have to screen their patients to see the expression of their target. NWBO's target antigen is expressed on all prostrate cancers. Additionally, with Dendreon's target, the level of expression goes down as the cancer progresses. The level of expression on NWBO's target goes up as the cancer progresses. As we learned from NWBO's Chairman Linda Powers, if your target is getting harder and harder for the vaccine to find and hit as the cancer progresses, that's not the characteristic you want in your target antigen.

    Another difference in the target antigens is NWBO's target is bound to the membrane of the tumor cell. "If the DCVax® hits our target," explains Linda Powers. "It hits the cell for sure. Dendreon's target is secreted by the cell, so while the target is close by, it is not necessarily bound to the cell in every instance. Antibodies can come along and glom onto to the target and not hit the cell itself, which means accuracy is an issue."

    Second factor: The manufacturing and purity of the product

    The active ingredient in both companies' vaccines is dendritic cells. That is an active pharmaceutical ingredient, it's the active agent that's doing the job. But according to data provided by Northwest Biotherapeutics, the percentage composition of Dendreon's product by the company's own published material is 15% antigen presenting cells -- dendritic cells and others. According to NWBO's published material, DCVax® is over 80% active ingredient. The official product release criteria are over 80% and Northwest Biotherapeutics' platform usually hits over 90%, thus the active ingredient in NWBO's vaccine is much more concentrated.

    Third factor: How is the product administered to the patient

    According to Powers, because there is such a low percentage of active ingredient in Dendreon's vaccine, they have to deliver a huge volume, and the only way to do it is intravenous infusion, which is how they deliver Provenge to their patients.

    This IV delivery can take over an hour. By contrast, because the active ingredient is so concentrated in the DCVax® vaccine, that NWBO only needs to administer a tiny volume of "just a few drops" and it's administered with a simple injection under the skin, like a flu shot or an insulin shot.

    Investors can read the complete report complete with more comments from Northwest Biotherapeutics Chairman Linda Powers today at BioMedReports.Com:

    biomedreports.com/component/content/a...

    In addition, Biotech investors interested in accessing the news portal's complete database of clinical trials and upcoming FDA decisions can access that information here:

    biomedreports.com/fda-calendar/fda-ca...

    About BioMedReports.Com

    BioMedReports.com is a news portal covering the biomedical news and financial sector. BioMedReports is not paid or compensated to report the news and developments of publicly traded companies.

    For more biomedical sector and investment news go to BioMedReports.com

    www.dailyfinance.com/quotes/northwest...

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  2. Debit or Credit 21 oktober 2015 18:41
    10000 stuks 5,12 gemiddeld.

    BETHESDA, Md., Oct. 21, 2015 /PRNewswire/ -- Northwest Biotherapeutics (NWBO) ("NW Bio"), a U.S. biotechnology company developing DCVax® personalized immune therapies for solid tumor cancers, announced today that the Company has entered into agreement for funding of $30 million from Woodford Investment Management in the UK ("Woodford").

    View photo
    .Northwest Biotherapeutics Logo.
    Woodford will purchase $30 million of the Company's common stock at $5.50 per share, for a total of 5,454,545 shares, raising Woodford's total holdings to 25,915,937 shares, or about 28.1% of the Company. The purchase will take place in a closing on or before October 22, 2015.

    NW Bio also announced that it has engaged Ondra Partners (www.ondra.com), a London-based corporate finance firm with a focus on value creation and an integrated approach to medium and long term financing and related initiatives.

    In connection with this financing, the Company has issued 0.7 million shares to Cognate BioServices on the same terms as Woodford's stock purchase, for certain current payment obligations, as well as completing the issuance of shares to Cognate that were approved and reported in November 2014, but had not yet been issued.

    "NW Bio has reported encouraging interim clinical data from both its DCVax-L and DCVax-Direct clinical programs, both last spring and recently, with patient survival exceeding expectations. With this new funding from Woodford we look forward to moving these clinical programs ahead vigorously while continuing to build our organization" commented Linda Powers, CEO of NW Bio.

    About Northwest Biotherapeutics

    Northwest Biotherapeutics is a biotechnology company focused on developing immunotherapy products to treat cancers more effectively than current treatments, without toxicities of the kind associated with chemotherapies, and on a cost-effective basis, in both the United States and Europe. The Company has a broad platform technology for DCVax dendritic cell-based vaccines. The Company's lead program is a 348-patient Phase III trial in newly diagnosed Glioblastoma multiforme (GBM), which is on a partial clinical hold in regard to new screening of patients. GBM is the most aggressive and lethal form of brain cancer, and is an "orphan disease." The Company is under way with a 60-patient Phase I/II trial with DCVax-Direct for all inoperable solid tumors cancers, with a primary efficacy endpoint of tumor regression. It has completed enrollment in the Phase I portion of the trial. The Company previously received clearance from the FDA for a 612-patient Phase III trial in prostate cancer. The Company conducted a Phase I/II trial with DCVax for metastatic ovarian cancer together with the University of Pennsylvania. In Germany, the Company has also received approval of a 5-year Hospital Exemption for the treatment of all gliomas (brain cancer) patients outside the clinical trial.

    Disclaimer

    Statements made in this news release that are not historical facts, including statements concerning future treatment of patients using DCVax and future clinical trials, are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as "expect," "believe," "intend," "design," "plan," "continue," "may," "will," "anticipate," and similar expressions are intended to identify forward-looking statements. Actual results may differ materially from those projected in any forward-looking statement. Specifically, there are a number of important factors that could cause actual results to differ materially from those anticipated, such as risks related to the Company's ongoing ability to raise additional capital, risks related to the Company's ability to enroll patients in its clinical trials and complete the trials on a timely basis, uncertainties about the clinical trials process, uncertainties about the timely performance of third parties, risks related to whether the Company's products will demonstrate safety and efficacy, risks related to the Company's and Cognate's abilities to carry out the intended manufacturing and expansions contemplated in the Cognate Agreements, risks related to the Company's ability to carry out the Hospital Exemption program and risks related to possible reimbursement and pricing. Additional information on these and other factors, including Risk Factors, which could affect the Company's results, is included in its Securities and Exchange Commission ("SEC") filings. Finally, there may be other factors not mentioned above or included in the Company's SEC filings that may cause actual results to differ materially from those projected in any forward-looking statement. You should not place undue reliance on any forward-looking statements. The Company assumes no obligation to update any forward-looking statements as a result of new information, future events or developments, except as required by securities laws.
  3. Tuut 7 oktober 2020 12:44


    News provided by
    Northwest Biotherapeutics

    Oct 05, 2020, 09:34 ET

    Share this article

    BETHESDA, Md., Oct. 5, 2020 /PRNewswire/ -- Northwest Biotherapeutics (OTCQB: NWBO) ("NW Bio"), a biotechnology company developing DCVax® personalized immune therapies for solid tumor cancers, today announced that the database for the Phase III trial of DCVax®-L for Gliobastoma has been locked.

    With the database now locked, the independent service firms managing the Clinical Trial are arranging for the independent statisticians to have access to the unblinded raw data from the Trial. Neither the Company nor any party other than the independent statisticians will have access to any unblinded data at this stage.

    The statisticians will proceed as quickly as possible with analyses of the raw data and prepare summaries of the Trial results for review by the Company, the Principal Investigator, the Steering Committee of the Trial, the Scientific Advisory Board, and a panel of independent brain cancer experts, who will analyze the data with the statisticians in preparation for public announcement and scientific publication.

    "We are excited to be so close to the finish line now, after such a long road" commented Linda Powers, the Company's CEO. "We are hopeful that DCVax®-L can become an important new treatment option for patients who urgently need more and better treatments for Glioblastoma brain cancer."

    "We are grateful to the independent service firms and the clinical trial sites who have worked so hard to complete the data collection and confirmation during many months of COVID restrictions and challenges," Ms. Powers continued. "We are also very grateful to our shareholders for their patience and support, which has made all this possible."

    About Northwest Biotherapeutics

    Northwest Biotherapeutics is a biotechnology company focused on developing personalized immunotherapy products designed to treat cancers more effectively than current treatments, without toxicities of the kind associated with chemotherapies, and on a cost-effective basis, in both North America and Europe. The Company has a broad platform technology for DCVax® dendritic cell-based vaccines. The Company's lead program is a 331-patient Phase III trial of DCVax®-L for newly diagnosed Glioblastoma multiforme (GBM). GBM is the most aggressive and lethal form of brain cancer, and is an "orphan disease." The Company is also pursuing development of DCVax®-Direct for inoperable solid tumor cancers. It has completed a 40-patient Phase I trial, and is preparing for Phase II trials. The Company previously conducted a Phase I/II trial with DCVax-L for advanced ovarian cancer together with the University of Pennsylvania.

    Disclaimer

    Statements made in this news release that are not historical facts, including statements concerning future treatment of patients using DCVax and future clinical trials, are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as "expect," "believe," "intend," "design," "plan," "continue," "may," "will," "anticipate," and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. We cannot guarantee that we actually will achieve the plans, intentions or expectations disclosed in our forward-looking statements and you should not place undue reliance on our forward-looking statements. Actual results may differ materially from those projected in any forward-looking statement. Specifically, there are a number of important factors that could cause actual results to differ materially from those anticipated, such as risks related to the Company's ability to enroll patients in its clinical trials and complete the trials on a timely basis, uncertainties about the clinical trials process, uncertainties about the timely performance of third parties, risks related to whether the Company's products will demonstrate safety and efficacy, risks related to the Company's ongoing ability to raise additional capital, and other risks included in the Company's Securities and Exchange Commission ("SEC") filings. Additional information on the foregoing risk factors and other factors, including Risk Factors, which could affect the Company's results, is included in its SEC filings. Finally, there may be other factors not mentioned above or included in the Company's SEC filings that may cause actual results to differ materially from those projected in any forward-looking statement. The Company assumes no obligation to update any forward-looking statements as a result of new information, future events or developments, except as required by securities laws.
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