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Jinxter schreef op 1 december 2022 14:13 :
News:
ir.orchard-tx.com/news-events/press-r... Cheers today
Weer een stapje verder...
News:www.globenewswire.com/news-release/20... Alle patiënten bereikten aanhoudende engraftment en suprafysiologische SGSH-enzymniveaus met mediane follow-up van 1,5 jaar Vier van de vijf patiënten toonden winst van cognitieve vaardigheden in overeenstemming met de ontwikkeling bij gezonde kinderen, waarbij één patiënt een duidelijke verbetering vertoonde in vergelijking met de natuurlijke geschiedenis van de ziekte Behandeling met OTL-201 werd over het algemeen goed verdragenconference call en webcast te hosten om 17:00 uur EST BOSTON en LONDEN, 12 december 2022 (GLOBE NEWSWIRE) -- Orchard Therapeutics (Nasdaq: ORTX),
Jinxter schreef op 12 december 2022 14:16 :
News:
www.globenewswire.com/news-release/20... Alle patiënten bereikten aanhoudende engraftment en suprafysiologische SGSH-enzymniveaus met mediane follow-up van 1,5 jaar
Vier van de vijf patiënten toonden winst van cognitieve vaardigheden in overeenstemming met de ontwikkeling bij gezonde kinderen, waarbij één patiënt een duidelijke verbetering vertoonde in vergelijking met de natuurlijke geschiedenis van de ziekte
Behandeling met OTL-201 werd over het algemeen goed verdragen
conference call en webcast te hosten om 17:00 uur EST BOSTON en LONDEN, 12 december 2022 (GLOBE NEWSWIRE) -- Orchard Therapeutics (Nasdaq: ORTX),
Helaas, helaas, de koers is weer flink aan het terug zakken. Gelukkkg heb ik gisteren niet bijgekocht. Eerst maar rustig afwachten, onderliggend ziet het er goed uit. Marktpotentieel is gelijk aan MLD. Bij goedkeuring USA, wordt dit weer verdubbeld, zoals eerlijk uitgelegd. Het vertrouwen in deze behandeling neemt toe, die imo superieur is aan alle bestaande behandelingen. Hoop dat het vuurtje snel overslaat, ook richting OTL-105. Tot die tijd, even radiostilte, al moet ik bekennen dat bij Pharvaris een enorme pump is geweest. Invitae wordt ook weer interessant. Voor degenen, die bemerken dat het rustig is op het forum, life goes on, en biotech is een kwestie van heel veel geduld. Salut
Dat was een mooi begin van het jaar...
Wat is de reden van de stijging deze 2 dagen? We zitten zomaar weer boven ons GAK dus we zijn best tevreden hoor ;-)
Ik vermoed een combinatie van twee dingen: 1. Afgelopen jaar zijn dit soort aandelen relatief harder gedaald. 2. Clinical Type B meeting with U.S. FDA to take place in early 2023 prior to OTL-200 BLA submission Bron: ir.orchard-tx.com/news-releases/news-...
Of het was dit:ir.orchard-tx.com/news-releases/news-... Global registrational trial expected to commence in the second half of 2023 BOSTON and LONDON, Jan. 05, 2023 (GLOBE NEWSWIRE) -- Orchard Therapeutics (Nasdaq: ORTX), a global gene therapy leader, today announced the U.S. Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application for OTL-203, a hematopoietic stem cell (HSC) gene therapy being developed for the treatment of the Hurler subtype of mucopolysaccharidosis type I (MPS-IH). The company expects to initiate a global registrational trial evaluating the efficacy and safety of OTL-203 compared to standard of care in the second half of 2023. “Based on data from the proof-of-concept trial, treatment with a single administration of OTL-203 has the potential to address a range of multisystemic manifestations of MPS-IH,” said Leslie Meltzer, Ph.D., chief medical officer of Orchard Therapeutics. “Our recent interactions with the FDA have been productive and we look forward to advancing this registrational study designed to generate the data necessary to enable global regulatory submissions and potentially provide an urgently needed new treatment option for the MPS-IH community.” The study is a multi-center, randomized, active controlled clinical trial designed to evaluate the efficacy and safety of OTL-203 in patients with MPS-IH compared to standard of care with allogeneic hematopoietic stem cell transplant (HSCT). A total of 40 patients with a confirmed diagnosis of MPS-IH who meet the study inclusion criteria will be randomized 1:1 to receive either OTL-203 or allogeneic HSCT. The study is powered to demonstrate superiority of OTL-203 over HSCT. The primary endpoint, which will be measured at two years post-treatment, comprises a composite of clinically meaningful outcomes, including death, the need for rescue treatment, treatment failure, immunological complications, as well as severe cognitive and growth impairment. Secondary endpoints include biochemical markers, additional clinical assessments, as well as safety and tolerability. The company expects to open up to six sites in the United States and Europe. “The complications associated with MPS-IH involve multiple organ systems and have a lasting impact on patients’ quality of life despite treatment with allogeneic HSCT,” said Paul Orchard, M.D., a study investigator and professor in the Division of Pediatric Blood and Marrow Transplantation and Cellular Therapy Program at the University of Minnesota Medical School. “Existing therapeutic options are associated with significant morbidity and mortality. There is experience acquired over decades that treatment with allogeneic HSCT does not adequately impact manifestations of the disorder such as growth and other skeletal issues. Furthermore, patients can still experience an irreversible decline in neurocognitive function. We look forward to facilitating this study to characterize the potential clinical impact of OTL-203 for MPS-IH patients.” In an earlier, single center proof-of-concept study, eight patients diagnosed with MPS-IH were treated with investigational OTL-203 between July 2018 and December 2019. Previously published results showed all patients had stable cognitive development post-treatment. In addition, at last follow-up (ranging from 12-24 months), all participants had progressed along expected growth percentiles of healthy children and exhibited longitudinal growth that was considered within the normal range adjusted for age and gender. Treatment with OTL-203 was generally well-tolerated with no indication of insertional oncogenesis and no evidence of clonal dominance due to integration into oncogenes reported to date. “MPS-IH is a devastating disease that places a significant burden on affected children and their families,” said Terri Klein, president and chief executive officer of the National MPS Society. “New treatment options are desperately needed to better address some of the more severe symptoms of the disease. We are encouraged by today's announcement and the hope that a one-time gene therapy could offer this community if approved.” About MPS-I Mucopolysaccharidosis type I (MPS-I) is a rare, inherited neurometabolic disease caused by a deficiency of the alpha-L-iduronidase (IDUA) lysosomal enzyme, which is required to break down sugar molecules called glycosaminoglycans (GAGs). The accumulation of GAGs across multiple organ systems results in multiple symptomatic manifestations of the disease including severe neurocognitive impairment, skeletal deformities, cardiovascular and pulmonary complications, impaired motor function, loss of hearing and corneal clouding. MPS-I occurs at an overall estimated frequency of one in every 100,000 live births. There are three subtypes of MPS-I. Approximately 60 percent of children born with MPS-I have the most severe subtype, called Hurler syndrome (MPS-IH), and rarely live past the age of 10 when untreated. Treatment options for MPS-I include hematopoietic stem cell transplant and chronic enzyme replacement therapy, both of which have limitations, such as inadequate impact on some of the more severe manifestations of disease, as well as significant morbidity and mortality. At present, Newborn Screening (NBS) for MPS-I has been established in multiple geographies, including the United States and Europe. About OTL-203 OTL-203 is an investigational hematopoietic stem cell gene therapy being developed for the treatment of MPS-IH. It uses a modified virus to insert a functional copy of the IDUA gene into a patient’s cells. OTL-203 is being developed in partnership with the San Raffaele Telethon Institute for Gene Therapy in Milan, Italy. OTL-203 has received rare pediatric disease and priority medicines (PRIME) designations from the FDA and European Medicines Agency, respectively. About Orchard Therapeutics At Orchard Therapeutics, our vision is to end the devastation caused by genetic and other severe diseases. We aim to do this by discovering, developing and commercializing new treatments that tap into the curative potential of hematopoietic stem cell (HSC) gene therapy. In this approach, a patient’s own blood stem cells are genetically modified outside of the body and then reinserted, with the goal of correcting the underlying cause of disease in a single treatment.
Deel 2 In 2018, the company acquired GSK’s rare disease gene therapy portfolio, which originated from a pioneering collaboration between GSK and the San Raffaele Telethon Institute for Gene Therapy in Milan, Italy. Today, Orchard is advancing a pipeline spanning pre-clinical, clinical and commercial stage HSC gene therapies designed to address serious diseases where the burden is immense for patients, families and society and current treatment options are limited or do not exist. Orchard has its global headquarters in London and U.S. headquarters in Boston. For more information, please visit www.orchard-tx.com , and follow us on Twitter and LinkedIn. Availability of Other Information About Orchard Investors and others should note that Orchard communicates with its investors and the public using the company website (www.orchard-tx.com), the investor relations website (ir.orchard-tx.com), and on social media (Twitter and LinkedIn), including but not limited to investor presentations and investor fact sheets, U.S. Securities and Exchange Commission filings, press releases, public conference calls and webcasts. The information that Orchard posts on these channels and websites could be deemed to be material information. As a result, Orchard encourages investors, the media, and others interested in Orchard to review the information that is posted on these channels, including the investor relations website, on a regular basis. This list of channels may be updated from time to time on Orchard’s investor relations website and may include additional social media channels. The contents of Orchard’s website or these channels, or any other website that may be accessed from its website or these channels, shall not be deemed incorporated by reference in any filing under the Securities Act of 1933. Forward-looking Statements This press release contains forward-looking statements, which are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. All statements that are not statements of historical facts are, or may be deemed to be, forward-looking statements. Forward-looking statements include express or implied statements relating to, among other things, Orchard’s business and product development strategy and goals, including the therapeutic potential of OTL-203, Orchard’s expectations with respect to regulatory submissions for its product candidates, including OTL-203, and Orchard’s expectations regarding its ongoing preclinical and clinical trials, including the timing of enrollment for clinical trials and release of additional preclinical and clinical data, and the likelihood that data from clinical trials will be positive and support further clinical development and regulatory approval of Orchard's product candidates. These statements are neither promises nor guarantees and are subject to a variety of risks and uncertainties, many of which are beyond Orchard’s control, which could cause actual results to differ materially from those contemplated in these forward-looking statements. In particular, these risks and uncertainties include, without limitation: the risk that prior results, such as signals of safety, activity or durability of effect, observed from clinical trials of OTL-203 will not continue or be repeated in Orchard’s ongoing or planned clinical trials of OTL-203, will be insufficient to support regulatory submissions or support or maintain marketing approval in the US or European Union, or that long-term adverse safety findings may be discovered; and the risk that any one or more of Orchard’s product candidates, including the OTL-203, will not be approved, successfully developed or commercialized. Given these uncertainties, the reader is advised not to place any undue reliance on such forward-looking statements. Other risks and uncertainties faced by Orchard include those identified under the heading "Risk Factors" in Orchard’s most recent annual or quarterly report filed with the U.S. Securities and Exchange Commission (SEC), as well as subsequent filings and reports filed with the SEC. The forward-looking statements contained in this press release reflect Orchard’s views as of the date hereof, and Orchard does not assume and specifically disclaims any obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as may be required by law. Dr. Paul Orchard is a paid consultant for Orchard Therapeutics.
Het is begonnen Passenger!
Ik heb een kleine positie, laatst nog een klein beetje bijgekocht. Ga vandaag denk mijn Gak halen!
Ik had ze jammergenoeg weg gedasn. Succes voor de zittenblijvers
Jinxter schreef op 5 januari 2023 14:15 :
Het is begonnen Passenger!
Zeker, buddy, en wat een Leidensweg is het geweest, zie voorgaande opmerkingen, reflecties en overdenkingen. Bijna een psychedelische, surrealistische gewaarwording. Haha, eerst naar de Westwood in DH, en mocht ik daar onverhoopt van herstellen, dan kijken voor het huis met een tuintje op het zuid-westen. Salut
Iris schreef op 5 januari 2023 15:17 :
Ik had ze jammergenoeg weg gedasn. Succes voor de zittenblijvers
Ai, jammer Iris. Weet dat geduld en schone zaak is.
Iris schreef op 5 januari 2023 15:17 :
Ik had ze jammergenoeg weg gedasn. Succes voor de zittenblijvers
Komen nog voldoende koop momenten Iris.
Concrete schreef op 5 januari 2023 19:05 :
[...]
Komen nog voldoende koop momenten Iris.
Zou ik niet vanuit gaan, 27M aandelen verhandeld, op een totaal van 120M. Dit aandeel kookt droog, en gaat daarna 5 keer minimaal over de kop, is mijn verwachting. Salut
The passenger schreef op 5 januari 2023 19:32 :
[...]
Zou ik niet vanuit gaan, 27M aandelen verhandeld, op een totaal van 120M.
Dit aandeel kookt droog, en gaat daarna 5 keer minimaal over de kop, is mijn verwachting.
Salut
Wat is 5x over de kop ? 0,60x2 x2x2x2x2. =. 19,20 €. Dat zou niet gek zijn maar zie ik toch niet binnen het jaar gebeuren.
Concrete schreef op 5 januari 2023 21:42 :
[...]
Wat is 5x over de kop ? 0,60x2 x2x2x2x2. =. 19,20 €. Dat zou niet gek zijn maar zie ik toch niet binnen het jaar gebeuren.
Ik had het over met factor 5, of stijging 500%. Helaas is de realiteitszin weer terug gekomen in het aandeel. Voorlopig vandaag weer zakken, en afwachten. Salut
The passenger schreef op 6 januari 2023 12:26 :
[...]
Ik had het over met factor 5, of stijging 500%. Helaas is de realiteitszin weer terug gekomen in het aandeel. Voorlopig vandaag weer zakken, en afwachten.
Salut
Voor de geïnteresseerden:ir.orchard-tx.com/news-releases/news-... En naast voortgang pipeline, is dit ook niet onverdienstelijk: The company ended 2022 with approximately $144 million of cash and investments. The burn rate was $2.9 million for the fourth quarter of 2022. Excluding offsets from one-time receipts of tax credits and real estate escrow funds, the burn rate would have been $23.4 million for the quarter. Moving forward, the company expects its burn rate in 2023 to continue declining as compared to 2022 due to an anticipated increase in revenue from Libmeldy product sales, continued savings realized by the March 2022 corporate restructuring, and ongoing management of operating expenses. BLA MLD vind ik wel lang duren, overigens, desalniettemin: Regulatory and Clinical Achievements for Investigational TherapiesOTL-200 for MLD: Engaged in a constructive, ongoing dialogue with the FDA throughout 2022 on the components of a planned BLA submission. Separately, patients in the U.S. were treated on compassionate use basis with EU CDMO manufacturing. OTL-203 for MPS-IH: Received clearance from the FDA for the Investigational New Drug (IND) application. A link to the full release is available here. OTL-201 for MPS-IIIA: Presented early clinical findings, including the first neurocognitive results, from the ongoing PoC study as part of an oral presentation at the 64th American Society of Hematology Annual Meeting & Exposition. Four out of five patients demonstrated gain of cognitive skills in line with development in healthy children with one patient showing a marked improvement compared to disease natural history. A link to the full release is available here. OTL-104 for NOD2-CD: Successfully developed and selected a vector design to advance a development candidate to IND-enabling activities using a suspension-based manufacturing process. Aardig, en niet te vergeten, een curative therapy voor NOD2 in aantocht. Kan niet voorspellen hoe de koers hierop reageert. Het is slechts weer een bevestiging dat de technologie van Orchard veelbelovend lijkt te zijn. Salut
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