Ontvang nu dagelijks onze kooptips!
word abonnee
sluiten ✕
Terug naar discussie overzicht
ProQR Therapeutics 2021
Volgen
Het was toch wel aardig geweest als ProQR even genoemd werd in dat artikel, het is dat er Sepofarsen staat anders hadden we het helemaal niet geweten. 9-11 april is er een presentatie www.proqr.com/press-releases/proqr-an...
In de NRC staat dit weekend een uitgebreid en interessant artikel over Leber congenitale amaurosis. Ik dacht even een artikel over Sepofarsen van Proqr te lezen maar het blijkt over de concurrent ? Luxturna te gaan, een medicijn wat sinds dit jaar vergoed wordt in Ned. Ik neem aan dat het om een iets ander gendefect gaat maar kan dit niet plaatsen. Wellicht kan iemand (Tom3?) die veel meer verstand heeft van de materie hier iets zinnigs over zeggen. Wel is gelijk duidelijk dat het een zeer, zeer kleine markt is en Proqr niet de enigste is.www.nrc.nl/nieuws/2021/04/02/virus-dr...
Nog een artikel uit België over het geneesmiddel luxturna. www.vrt.be/vrtnws/nl/2021/04/01/genth... Wat hier ook aangehaald wordt is dat gentherapie peper duur is. Ik dacht dat RNA therapy veel betaalbaarder is? Gentherapie heeft volgens mij ook risico's zoals off-target effects. Ik denk dat RNA therapy goedkoper, veiliger, en sneller op de markt te brengen is.
ProQR Announces Closing of Underwritten Public Offering of Ordinary Shares with Full Exercise of Underwriters’ Option to Purchase Additional Shares LEIDEN, Netherlands and CAMBRIDGE, Mass., April 05, 2021 (GLOBE NEWSWIRE) -- ProQR Therapeutics N.V. (Nasdaq: PRQR), a company dedicated to changing lives through the creation of transformative RNA therapies for inherited retinal diseases (IRDs), today announced the closing of its previously announced underwritten public offering of 13,846,154 ordinary shares at a price to the public of $6.50 per share. All of the shares were offered by ProQR. The closing included the full exercise of the underwriters’ option to purchase up to 2,076,923 additional ordinary shares at the public offering price, less underwriting discounts and commissions. Gross proceeds from the offering totaled approximately $103.5 million, before deducting underwriting discounts and commissions and offering expenses. Continue reading this press release Or find all press releases here.
Mooi, grofweg 200 mln in kas, ongeveer 50 mln cashburn per jaar. 1 a 2 producten die binnen 4 jaar omzet gaan genereren. De techniek werkt, nieuwe onderzoeken voor in de pijplijn voor het uitkiezen. Goede vooruitzichten!
tipranks verhoogd het koers doel van 20 naar 35 dollar voor april 2022
Wat heb ik met dit aandeel toch een haat liefde verhouding en een ontzettend hoog fomo gehalte. Je wilt zo graag meer weten en horen van dit aandeel , maar het blijft maar stil, tot een aantal weken geleden. de dag waar je al lang op hebt gewacht maar dat je weer van een koude kermis thuis komt of blij wordt gemaakt met een dood vogeltje, tis maar net wat voor benaming je er aan wilt verbinden. Maar ook juist de communicatie die zo slecht is stelt je weer in staat om nog liever gisteren dan vandaag het aandeel te hebben verkocht. al deze tegenstribbelingen zorgen er bij mij uiteindelijk voor dat ik maar gewoon blijf zitten en vertrouw op de expertise van het bedrijf.
Dat ProQR aan iets spannends bezig is neem ik serieus, maar ik kan me niet ad indruk onttrekken dat er giga met de koers gespeeld wordt en vermoed (indirect) handel met voorkennis bij betrokken financiële partijen (via lek begeleidende emissieleider?). Toeval bestaat...tot het mathematisch niet meer te verklaren is!
Gisteren wat bijgekocht, ik had ook liever gezien dat de koers was doorgestegen. Het fomo gehalte is echter bij mij ook erg hoog. Mocht de koers nog lager worden gezet, dan blijf ik plukjes bijkopen. Sinds de laatste resultaten en de emissie lijkt het me geen gokaandeel meer, maar een veilige belegging waar nog veel fantasie in zit. Eens ook dat de betrokken financiële partijen de koersen kunnen sturen. er zit niets anders op dan met ze mee te deinen. Hogere koersen zullen uiteindelijk ook in hun voordeel zijn lijkt me.
ProQR Announces Publication in Nature Medicine for Sepofarsen in Leber Congenital Amaurosis 10 LEIDEN, Netherlands & CAMBRIDGE, Mass., April 13, 2021 (GLOBE NEWSWIRE) -- ProQR Therapeutics N.V. (Nasdaq:PRQR), a company dedicated to changing lives through the creation of transformative RNA therapies for severe genetic rare diseases, today announced the publication in the scientific journal Nature Medicine titled “Durable vision improvement after a single treatment with antisense oligonucleotide sepofarsen: a case report” describing durable vision improvement after treatment with sepofarsen in a clinical trial for CEP290 mediated Leber congenital amaurosis 10 (LCA10). “We are excited to share these findings with the scientific and medical community,” said lead author Professor Artur V. Cideciyan, Ph.D., one of the co-investigators at the Scheie Eye Institute of the University of Pennsylvania. “Treatment with sepofarsen resulted in substantial, concordant and enduring improvement in more than a dozen different subjective and objective measurements of visual function as well as retinal structure.” “We are highly encouraged by the data showing sepofarsen had such a beneficial effect on this child’s vision,” said Aniz Girach, MD, Chief Medical Officer of ProQR, “The visual field improvements observed indicate that RNA therapy could potentially be used to treat early stage disease, which is enabled by the broad distribution of intravitreal RNA therapy throughout the retina.” Published results highlight a patient who is homozygous for the c.2991+1655A>G mutation in CEP290 and was part of a larger cohort in the Phase 1/2 clinical trial. The patient was studied for 15 months after intravitreal treatment with sepofarsen. Concordant measures of visual function and retinal structure including visual acuity, light sensitivity and visual fields, reached a substantial efficacy peak near three months after injection and remained better than baseline at 15 months. About Leber Congenital Amaurosis 10 (LCA10) Leber congenital amaurosis (LCA) is the most common cause of blindness due to genetic disease in children. It consists of a group of diseases of which LCA10 is the most frequent and one of the most severe forms. LCA10 is caused by mutations in the CEP290 gene, of which the c.2991+1655A>G mutation has the highest prevalence. LCA10 leads to early loss of vision causing most people to lose their sight in the first few years of life. To date, there are no treatments approved that treat the underlying cause of the disease. Approximately 2,000 people in the Western world have LCA10 because of this mutation. About Sepofarsen Sepofarsen (QR-110) is being evaluated in the pivotal Phase 2/3 Illuminate trial and is a first-in-class investigational RNA therapy designed to address the underlying cause of Leber congenital amaurosis 10 due to the c.2991+1655A>G mutation (also known as the p.Cys998X mutation) in the CEP290 gene. The c.2991+1655A>G mutation leads to aberrant splicing of the mRNA and non-functional CEP290 protein. Sepofarsen is designed to enable normal splicing, resulting in restoration of normal (wild type) CEP290 mRNA and subsequent production of functional CEP290 protein. Sepofarsen is intended to be administered through intravitreal injections in the eye and has been granted orphan drug designation in the United States and the European Union and received fast-track designation and rare pediatric disease designation from the FDA as well as access to the PRIME scheme by the EMA. About ProQR ProQR Therapeutics is dedicated to changing lives through the creation of transformative RNA therapies for the treatment of severe genetic rare diseases such as Leber congenital amaurosis 10, Usher syndrome and retinitis pigmentosa. Based on our unique proprietary RNA repair platform technologies we are growing our pipeline with patients and loved ones in mind. Learn more about ProQR at www.proqr.com. Forward Looking Statements
Editas Medicine Falls as Goldman Sachs Initiates the Stock at Sell Editas is initiated with a sell rating and $20 price target at Goldman Sachs. TONY OWUSU Editas Medicine (EDIT) - Get Report dropped Friday after analysts at Goldman Sachs initiated coverage on shares off the company with a sell rating and a price target of $20 a share, a Wall Street low. The firm said the risk-reward dynamic was skewed negatively for the clinical stage genome editing company. Initial results from the company's experimental Crispr gene editing product EDIT-11 in a rare eye disease may not generate enough productive editing to meaningfully improve patients' vision, analyst Madhu Kumar said in his note initiating coverage on the stock. Editas shares dropped 12% to $36 a share Friday. Read More: Gene Editing Emerges From the LabAlso weighing on the company was competition from ProQR Therapeutics for treatment of the disease known as Leber's congenital amaurosis. Kumar was more bullish on Apellis Pharmaceuticals (APLS) - Get Report and Dicerna Pharmaceuticals (DRNA) - Get Report which were both given buy ratings. Apellis has a $130 price target and Dicerna was given a $48 price target; both are Wall Street highs. The firm expects mergers and acquisitions to be selective in the industry in the near-term due to lingering questions around current high valuations. Gene editing has been in the spotlight in 2021 after Cathie Wood, the founder of ARK Investment Management, said that gene-editing might be an even bigger investment opportunity than Tesla (TSLA) - Get Report. Specifically she favored Editas, CRISPR Therapeutics (CRSP) - Get Report and Intellia Therapeutics (NTLA) - Get Report in an interview on Bloomberg in December. She explained that investing in genomics and gene-editing stocks should be an even better longer-term investment than Tesla because the technology has the potential to cure disease. TAGSPHARMACEUTICALSHEALTHBIOTECHNOLOGY Tony Owusu BY TONY OWUSU © 2021 TheStreet, Inc. All rights reserved. Action Alerts PLUS is a registered trademark of TheStreet, Inc.
Weer 2 presentaties; -ProQr management will host 1x1 meetings through the Kempen Life Sciences Conference 2021 Thematic Virtual Series on April 28, 2021. -A virtual oral presentation of data from the Company’s Phase 1/2 InSight extension trial of sepofarsen and live Q&A session at the Association for Research in Vision and Ophthalmology (ARVO) held May 1-7, 2021
3 mei 2021: Stifel analyst Dae Gon Ha initiates coverage on ProQR Therapeutics N.V. (NASDAQ: PRQR) with a Buy rating and a price target of $20.00.
ProQR Therapeutics offers a de-risked opportunity: Stifelseekingalpha.com/news/3689398-proqr-t...
ProQR Therapeutics and Yarrow Biotechnology, an RTW Investments, LP Incubated Company, Announce Exclusive Worldwide License and Discovery Collaboration for Undisclosed Targetwww.proqr.com/press-releases/proqr-th...
Daniel A. De Boer: 'we are pleased to partner with yarrow tot advance our technology in applications OUTSIDE the eye'. Spannend, ik ben erg benieuwd waarop men het onderzoek, naast het oog, gaat richten. Dan wordt er een hele nieuwe doelgroep aangeboord. Een flink bedrag ook om 'upfront' te krijgen.
Het platform/de technologie wordt al langer breder ingezet: www.proqr.com/spin-outs De website van Amylon vind je hier: amylon.com/ De website van Wings is uit de lucht: www.wings-tx.com/
Dank, ik begrijp overigens niets van dit koersverloop.
Geduld is je vriend, zag je vroeger ook bij GLPG....bij goed fundamenteel lange termijn nieuws krijg je eerst het tegenovergestelde van wat je verwacht...ik heb er gebruik van gemaakt en bijgekocht op 6,15.
Aantal posts per pagina:
20
50
100
Direct naar Forum
-- Selecteer een forum --
Koffiekamer
Belastingzaken
Beleggingsfondsen
Beursspel
BioPharma
Daytraders
Garantieproducten
Opties
Technische Analyse
Technische Analyse Software
Vastgoed
Warrants
10 van Tak
4Energy Invest
Aalberts
AB InBev
Abionyx Pharma
Ablynx
ABN AMRO
ABO-Group
Acacia Pharma
Accell Group
Accentis
Accsys Technologies
ACCSYS TECHNOLOGIES PLC
Ackermans & van Haaren
ADMA Biologics
Adomos
AdUX
Adyen
Aedifica
Aegon
AFC Ajax
Affimed NV
ageas
Agfa-Gevaert
Ahold
Air France - KLM
Airspray
Akka Technologies
AkzoNobel
Alfen
Allfunds Group
Allfunds Group
Almunda Professionals (vh Novisource)
Alpha Pro Tech
Alphabet Inc.
Altice
Alumexx ((Voorheen Phelix (voorheen Inverko))
AM
Amarin Corporation
Amerikaanse aandelen
AMG
AMS
Amsterdam Commodities
AMT Holding
Anavex Life Sciences Corp
Antonov
Aperam
Apollo Alternative Assets
Apple
Arcadis
Arcelor Mittal
Archos
Arcona Property Fund
arGEN-X
Aroundtown SA
Arrowhead Research
Ascencio
ASIT biotech
ASMI
ASML
ASR Nederland
ATAI Life Sciences
Atenor Group
Athlon Group
Atrium European Real Estate
Auplata
Avantium
Axsome Therapeutics
Azelis Group
Azerion
B&S Group
Baan
Ballast Nedam
BALTA GROUP N.V.
BAM Groep
Banco de Sabadell
Banimmo A
Barco
Barrick Gold
BASF SE
Basic-Fit
Basilix
Batenburg Beheer
BE Semiconductor
Beaulieulaan
Befimmo
Bekaert
Belgische aandelen
Beluga
Beter Bed
Bever
Binck
Biocartis
Biophytis
Biosynex
Biotalys
Bitcoin en andere cryptocurrencies
bluebird bio
Blydenstijn-Willink
BMW
BNP Paribas S.A.
Boeing Company
Bols (Lucas Bols N.V.)
Bone Therapeutics
Borr Drilling
Boskalis
BP PLC
bpost
Brand Funding
Brederode
Brill
Bristol-Myers Squibb
Brunel
C/Tac
Campine
Canadese aandelen
Care Property Invest
Carmila
Carrefour
Cate, ten
CECONOMY
Celyad
CFD's
CFE
CGG
Chinese aandelen
Cibox Interactive
Citygroup
Claranova
CM.com
Co.Br.Ha.
Coca-Cola European Partners
Cofinimmo
Cognosec
Colruyt
Commerzbank
Compagnie des Alpes
Compagnie du Bois Sauvage
Connect Group
Continental AG
Corbion
Core Labs
Corporate Express
Corus
Crescent (voorheen Option)
Crown van Gelder
Crucell
CTP
Curetis
CV-meter
Cyber Security 1 AB
Cybergun
D'Ieteren
D.E Master Blenders 1753
Deceuninck
Delta Lloyd
DEME
Deutsche Cannabis
DEUTSCHE POST AG
Dexia
DGB Group
DIA
Diegem Kennedy
Distri-Land Certificate
DNC
Dockwise
DPA Flex Group
Draka Holding
DSC2
DSM
Duitse aandelen
Dutch Star Companies ONE
Duurzaam Beleggen
DVRG
Ease2pay
Ebusco
Eckert-Ziegler
Econocom Group
Econosto
Edelmetalen
Ekopak
Elastic N.V.
Elia
Endemol
Energie
Energiekontor
Engie
Envipco
Erasmus Beursspel
Eriks
Esperite (voorheen Cryo Save)
EUR/USD
Eurobio
Eurocastle
Eurocommercial Properties
Euronav
Euronext
Euronext
Euronext.liffe Optiecompetitie
Europcar Mobility Group
Europlasma
EVC
EVS Broadcast Equipment
Exact
Exmar
Exor
Facebook
Fagron
Fastned
Fingerprint Cards AB
First Solar Inc
FlatexDeGiro
Floridienne
Flow Traders
Fluxys Belgium D
FNG (voorheen DICO International)
Fondsmanager Gezocht
ForFarmers
Fountain
Frans Maas
Franse aandelen
FuelCell Energy
Fugro
Futures
FX, Forex, foreign exchange market, valutamarkt
Galapagos
Gamma
Gaussin
GBL
Gemalto
General Electric
Genfit
Genmab
GeoJunxion
Getronics
Gilead Sciences
Gimv
Global Graphics
Goud
GrandVision
Great Panther Mining
Greenyard
Grolsch
Grondstoffen
Grontmij
Guru
Hagemeyer
HAL
Hamon Groep
Hedge funds: Haaien of helden?
Heijmans
Heineken
Hello Fresh
HES Beheer
Hitt
Holland Colours
Homburg Invest
Home Invest Belgium
Hoop Effektenbank, v.d.
Hunter Douglas
Hydratec Industries (v/h Nyloplast)
HyGear (NPEX effectenbeurs)
HYLORIS
Hypotheken
IBA
ICT Automatisering
Iep Invest (voorheen Punch International)
Ierse aandelen
IEX Group
IEX.nl Sparen
IMCD
Immo Moury
Immobel
Imtech
ING Groep
Innoconcepts
InPost
Insmed Incorporated (INSM)
IntegraGen
Intel
Intertrust
Intervest Offices & Warehouses
Intrasense
InVivo Therapeutics Holdings Corp (NVIV)
Isotis
JDE PEET'S
Jensen-Group
Jetix Europe
Johnson & Johnson
Just Eat Takeaway
Kardan
Kas Bank
KBC Ancora
KBC Groep
Kendrion
Keyware Technologies
Kiadis Pharma
Kinepolis Group
KKO International
Klépierre
KPN
KPNQwest
KUKA AG
La Jolla Pharmaceutical
Lavide Holding (voorheen Qurius)
LBC
LBI International
Leasinvest
Logica
Lotus Bakeries
Macintosh Retail Group
Majorel
Marel
Mastrad
Materialise NV
McGregor
MDxHealth
Mediq
Melexis
Merus Labs International
Merus NV
Microsoft
Miko
Mithra Pharmaceuticals
Montea
Moolen, van der
Mopoli
Morefield Group
Mota-Engil Africa
MotorK
Moury Construct
MTY Holdings (voorheen Alanheri)
Nationale Bank van België
Nationale Nederlanden
NBZ
Nedap
Nedfield
Nedschroef
Nedsense Enterpr
Nel ASA
Neoen SA
Neopost
Neovacs
NEPI Rockcastle
Netflix
New Sources Energy
Neways Electronics
NewTree
NexTech AR Solutions
NIBC
Nieuwe Steen Investments
Nintendo
Nokia
Nokia OYJ
Nokia Oyj
Novacyt
NOVO-NORDISK AS
NPEX
NR21
Numico
Nutreco
Nvidia
NWE Nederlandse AM Hypotheek Bank
NX Filtration
NXP Semiconductors NV
Nyrstar
Nyxoah
Océ
OCI
Octoplus
Oil States International
Onconova Therapeutics
Ontex
Onward Medical
Onxeo SA
OpenTV
OpGen
Opinies - Tilburg Trading Club
Opportunty Investment Management
Orange Belgium
Oranjewoud
Ordina Beheer
Oud ForFarmers
Oxurion (vh ThromboGenics)
P&O Nedlloyd
PAVmed
Payton Planar Magnetics
Perpetuals, Steepeners
Pershing Square Holdings Ltd
Personalized Nursing Services
Pfizer
Pharco
Pharming
Pharnext
Philips
Picanol
Pieris Pharmaceuticals
Plug Power
Politiek
Porceleyne Fles
Portugese aandelen
PostNL
Priority Telecom
Prologis Euro Prop
ProQR Therapeutics
PROSIEBENSAT.1 MEDIA SE
Prosus
Proximus
Qrf
Qualcomm
Quest For Growth
Rabobank Certificaat
Randstad
Range Beleggen
Recticel
Reed Elsevier
Reesink
Refresco Gerber
Reibel
Relief therapeutics
Renewi
Rente en valuta
Resilux
Retail Estates
RoodMicrotec
Roularta Media
Royal Bank Of Scotland
Royal Dutch Shell
RTL Group
RTL Group
S&P 500
Samas Groep
Sapec
SBM Offshore
Scandinavische (Noorse, Zweedse, Deense, Finse) aandelen
Schuitema
Seagull
Sequana Medical
Shurgard
Siemens Gamesa
Sif Holding
Signify
Simac
Sioen Industries
Sipef
Sligro Food Group
SMA Solar technology
Smartphoto Group
Smit Internationale
Snowworld
SNS Fundcoach Beleggingsfondsen Competitie
SNS Reaal
SNS Small & Midcap Competitie
Sofina
Softimat
Solocal Group
Solvac
Solvay
Sopheon
Spadel
Sparen voor later
Spectra7 Microsystems
Spotify
Spyker N.V.
Stellantis
Stellantis
Stern
Stork
Sucraf A en B
Sunrun
Super de Boer
SVK (Scheerders van Kerchove)
Syensqo
Systeem Trading
Taiwan Semiconductor Manufacturing Company (TSMC)
Technicolor
Tele Atlas
Telegraaf Media
Telenet Groep Holding
Tencent Holdings Ltd
Tesla Motors Inc.
Tessenderlo Group
Tetragon Financial Group
Teva Pharmaceutical Industries
Texaf
Theon International
TherapeuticsMD
Thunderbird Resorts
TIE
Tigenix
Tikkurila
TINC
TITAN CEMENT INTERNATIONAL
TKH Group
TMC
TNT Express
TomTom
Transocean
Trigano
Tubize
Turbo's
Twilio
UCB
Umicore
Unibail-Rodamco
Unifiedpost
Unilever
Unilever
uniQure
Unit 4 Agresso
Univar
Universal Music Group
USG People
Vallourec
Value8
Value8 Cum Pref
Van de Velde
Van Lanschot
Vastned
Vastned Retail Belgium
Vedior
VendexKBB
VEON
Vermogensbeheer
Versatel
VESTAS WIND SYSTEMS
VGP
Via Net.Works
Viohalco
Vivendi
Vivoryon Therapeutics
VNU
VolkerWessels
Volkswagen
Volta Finance
Vonovia
Vopak
Warehouses
Wave Life Sciences Ltd
Wavin
WDP
Wegener
Weibo Corp
Wereldhave
Wereldhave Belgium
Wessanen
What's Cooking
Wolters Kluwer
X-FAB
Xebec
Xeikon
Xior
Yatra Capital Limited
Zalando
Zenitel
Zénobe Gramme
Ziggo
Zilver - Silver World Spot (USD)
Premium
Word nu abonnee van IEX en krijg onbeperkt toegang tot onze (koop)tips en succesvolle modelportefeuilles. Nu 3 maanden voor slechts €19,95! Profiteer van 58% korting!
Word abonnee