moaventtoch schreef op 28 mei 2020 12:25:
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monacochick schreef op 28 mei 2020 11:25:
Hebben julie dit gezien? Een super interessant artikel van 16.05 uit Barcelona dat voorlegd dat covid de protein c1-INH zou verminderen. Dat is precies de protein dat in HAE patienten te kort is et dat Ruconest compenseerd. Dus het artikel geeft een theoretische basis voor de zwitserse clinische trial.
Thomson, T.M.; Toscano, E.; Casis, E.; Paciucci, R. C1-INH and the Contact System in COVID-19-Associated Coagulopathy. Preprints 2020, 2020050262 (doi: 10.20944/preprints202005.0262.v1).
conclusie.
Unlike all currently prevailing hypotheses, which focus on non-pathogenspecific mechanisms, we propose a pathogen-specific mechanism by which
non-structural SARS-CoV proteins bind to C1 esterase inhibitor (C1-INH,
encoded by SERPING1), potentially causing a deficiency in this regulator of the
contact and complement systems. Although it requires experimental
confirmation, such as protein-protein binding and C1-INH enzymatic assays, the
plausibility of our hypothesis is supported by the multiplicity of interactions
observed between CoV proteins and C1-INH. Importantly, our hypothesis
provides a single mechanism that explains many clinical, pathological and
laboratory findings associated with severe COVID-19 and opens up a whole
new set of therapeutic options to tackle the most deadly manifestations of this
viral disease